6-Aza-spiro[3.4]octane

Base Information

• Chemical Name: 6-Aza-spiro[3.4]octane
• CAS No.: 765-64-0
• Molecular Formula: C7H13N
• Molecular Weight: 111.18482
• Hs Code.: 2933990090
• Mol file: 765-64-0.mol

Synonyms:6-Aza-spiro[3.4]octane;6-Aza-spiro[3.4]octane ox...;6-Aza-spiro[3.4]octane heMioxalate;6-Aza-spiro[3.4]octane oxalate

Chemical Property of 6-Aza-spiro[3.4]octane

Chemical Property:

• Boiling Point: 162.0±8.0 °C(Predicted)
• PKA: 11.41±0.20(Predicted)
• PSA: 12.03000
• Density: 0.96±0.1 g/cm3(Predicted)
• LogP: 1.47880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-Azaspiro[3.4]octane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Azaspiro[3.4]octane Hemioxalate is the Hemioxalate salt of 6-Azaspiro[3.4]octane, a reactant in the preparation of tetrahydroisoquinolin derivatives as CXCR3 receptor agonists.

Technology Process of 6-Aza-spiro[3.4]octane

There total 1 articles about 6-Aza-spiro[3.4]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-aza-spiro[3.4]octane (765-64-0)

Guidance literature:

6-Azaspiro<3.4>octan-5-on, LiAlH4 in THF; Erwaermen;

Reference yield: 75.0%

6-aza-spiro[3.4]octane (765-64-0) + 1-(3,4-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid → (1-(3,4-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)(6-azaspiro[3.4]octan-6-yl)methanone

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/acsmedchemlett.9b00369

Reference yield:

6-aza-spiro[3.4]octane (765-64-0) + N-[3-bromo-4-(4-propylpiperazine-1-carbonyl)phenyl]cyclopropanecarboxamide → N-(4-(4-propylpiperazine-1-carbonyl)-3-(6-azaspiro[3.4]octan-6-yl)phenyl)cyclopropanecarboxamide

Guidance literature:

With (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one, palladium(II) complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 120 ℃; Schlenk technique;

Downstream raw materials:

N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

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