Methyl 6-oxospiro[3.3]heptane-2-carboxylate

Base Information

• Chemical Name: Methyl 6-oxospiro[3.3]heptane-2-carboxylate
• CAS No.: 1138480-98-4
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Hs Code.: 2918300090
• Mol file: 1138480-98-4.mol

Synonyms:C-8226;

Chemical Property of Methyl 6-oxospiro[3.3]heptane-2-carboxylate

Chemical Property:

• Boiling Point: 259.9±40.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 0.91870
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl6-Oxospiro[3.3]heptane-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-oxospiro[3.3]heptane-2-carboxylate

There total 1 articles about Methyl 6-oxospiro[3.3]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylenecyclobutanecarbonitrile (15760-35-7) → 6-oxo-spiro[3.3]heptane-2-carboxylic acid methyl ester (1138480-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1: water; potassium hydroxide / ethanol / 16 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide

3: copper; zinc; trichlorophosphate / acetic acid methyl ester / 0 - 20 °C

With water; copper; caesium carbonate; potassium hydroxide; zinc; trichlorophosphate; In ethanol; acetic acid methyl ester; N,N-dimethyl-formamide;

Reference yield: 95.0%

dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate (61260-15-9) + 6-oxo-spiro[3.3]heptane-2-carboxylic acid methyl ester (1138480-98-4) → methyl 6-(3-oxoisobenzofuran-1(3H)-ylidene)spiro[3.3]heptane-2-carboxylate

Guidance literature:

With caesium carbonate; In isopropyl alcohol; at 20 ℃; for 16h;

Reference yield: 83.0%

6-oxo-spiro[3.3]heptane-2-carboxylic acid methyl ester (1138480-98-4) + 1-(4-fluorophenyl)-4-methoxyindole → methyl 6-[1-(4-fluorophenyl)-4-methoxyindol-3-yl]spiro[3.3]heptane-2-carboxylate

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 50 ℃; for 72h;

upstream raw materials:

3-methylenecyclobutanecarbonitrile

Downstream raw materials:

methyl 6-(benzylimino)spiro[3.3]heptane-2-carboxylate

Refernces

• 1、 -. "CHEMICAL COMPOUNDS AS H-PGDS INHIBITORS". . . Retrieved 2019/01/08.