1-Oxa-7-azaspiro[3.5]nona...

Base Information

• Chemical Name: 1-Oxa-7-azaspiro[3.5]nona...
• CAS No.: 38674-21-4
• Molecular Formula: C7H13NO
• Molecular Weight: 127.18
• Hs Code.: 2934999090
• Mol file: 38674-21-4.mol

Synonyms:1-Oxa-7-azaspiro[3.5]nona...

Chemical Property of 1-Oxa-7-azaspiro[3.5]nona...

Chemical Property:

• Boiling Point: 208℃
• Flash Point: 74℃
• PSA: 21.26000
• Density: 1.04
• LogP: 0.85770
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

1-Oxa-7-azaspiro[3.5]nonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxa-7-azaspiro[3.5]nona...

There total 1 articles about 1-Oxa-7-azaspiro[3.5]nona... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 1-oxa-7-azaspiro[3.5]nonane-7-carboxylate (864684-96-8) → 1-oxa-7-azaspiro[3.5]nonane (38674-21-4)

Guidance literature:

With trifluoroacetic acid; for 2h;

Reference yield:

1-oxa-7-azaspiro[3.5]nonane (38674-21-4) → 4-((5-(1-oxa-7-azaspiro[3.5]nonan-7-yl)pyridin-2-yl)amino)-2-(2,6-difluorophenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Guidance literature:

Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / dimethyl sulfoxide / 2 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 1 h

3: potassium phosphate / 1,4-dioxane / 0.33 h / 100 °C

With potassium phosphate; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; In 1,4-dioxane; methanol; dimethyl sulfoxide;

upstream raw materials:

tert-butyl 1-oxa-7-azaspiro[3.5]nonane-7-carboxylate