3-Aminomethyl-3-[bis(phen...

Base Information

• Chemical Name: 3-Aminomethyl-3-[bis(phen...
• CAS No.: 1021392-84-6
• Molecular Formula: C18H22N2O
• Molecular Weight: 282.385
• Hs Code.: 2932999099
• Mol file: 1021392-84-6.mol

Synonyms:3-Aminomethyl-3-[bis(phenylmethyl)amino]oxetane;

Chemical Property of 3-Aminomethyl-3-[bis(phen...

Chemical Property:

• Boiling Point: 409.9±40.0 °C(Predicted)
• PKA: 9.65±0.29(Predicted)
• PSA: 38.49000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 3.11680

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Aminomethyl-3-[bis(phenylmethyl)amino]oxetane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Aminomethyl-3-[bis(phenylmethyl)amino]oxetane is used as a reactant in the preparation of spiropyrido[1,2-a]pyrazine compounds useful as HIV integrase inhibitors for treatment or prevention of HIV infection and AIDS.

Technology Process of 3-Aminomethyl-3-[bis(phen...

There total 2 articles about 3-Aminomethyl-3-[bis(phen... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(dibenzylamino)oxetane-3-carbonitrile (1021393-00-9) → 3-(aminomethyl)-N,N-dibenzyloxetane-3-amine (1021392-84-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Cooling with ice;

Reference yield:

dibenzylamine (103-49-1) → 3-(aminomethyl)-N,N-dibenzyloxetane-3-amine (1021392-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethyl acetate; water / 5 - 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Cooling with ice

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 93.0%

3-(aminomethyl)-N,N-dibenzyloxetane-3-amine (1021392-84-6) → C18H20N4O

Guidance literature:

With fluorosulfonyl azide; potassium hydrogencarbonate; In tert-butyl methyl ether; water; N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

DOI:10.1038/s41586-019-1589-1

upstream raw materials:

3-(dibenzylamino)oxetane-3-carbonitrile

dibenzylamine

Downstream raw materials:

(3-aminomethyl-oxetan-3-yl)-benzyl-amine

N-{[3-(dibenzylamino)oxetan-3-yl]methyl}-2-(8-methoxy-1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-amine

(3-dibenzylamino-oxetan-3-ylmethyl)carbamic acid tert-butyl ester

Refernces

• 1、 -. "NEW IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS". Page/Page column 48. . Retrieved 2008/06/13.