1-Boc-azetidine-3-carboxy...

Base Information

• Chemical Name: 1-Boc-azetidine-3-carboxy...
• CAS No.: 1001907-44-3
• Molecular Formula: C9H17N3O3
• Molecular Weight: 215.252
• Hs Code.: 2933990090
• Mol file: 1001907-44-3.mol

Synonyms:3-hydrazinocarbonyl-azetidine-1-carboxylic acid tert-butyl ester;tert-butyl 3-(hydrazinylcarbonyl)azetidine-1-carboxylate;1-BOC-3-HYDRAZINOCARBONYL-AZETIDINE;

Chemical Property of 1-Boc-azetidine-3-carboxy...

Chemical Property:

• PSA: 84.66000
• LogP: 0.87230
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(5-Amino-1,3,4-oxadiazol-2-yl)azetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-azetidine-3-carboxy...

There total 1 articles about 1-Boc-azetidine-3-carboxy... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid (142253-55-2) → tert-butyl 3-(hydrazinylcarbonyl)azetidine-1-carboxylate (1001907-44-3)

Guidance literature:

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃;

With hydrazine hydrate; In dichloromethane; at 20 ℃;

Reference yield: 81.0%

(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid (1174020-25-7,2064219-13-0) + tert-butyl 3-(hydrazinylcarbonyl)azetidine-1-carboxylate (1001907-44-3) → tert-butyl 3-[(2-{[(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}hydrazinyl)carbonyl]azetidine-1-carboxylate (1452467-71-8)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield: 60.0%

tert-butyl 3-(hydrazinylcarbonyl)azetidine-1-carboxylate (1001907-44-3) + (1R,4S)-7-(benzyloxy)-6-oxo-5,7-diazaspiro[bicyclo[3.2.1]octane-2,1'-cyclopropane]-4-carboxylic acid → tert-butyl 3-[(2-{[(1R,4S)-7-(benzyloxy)-6-oxo-5,7-diazaspiro[bicyclo[3.2.1]octane-2,1'-cyclopropan]-4-yl]carbonyl}hydrazinyl)carbonyl]azetidine-1-carboxylate

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

upstream raw materials:

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

Downstream raw materials:

tert-butyl 3-[(2-{[(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}hydrazinyl)carbonyl]azetidine-1-carboxylate