3-Aminomethyl-3-fluoropiperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3-Aminomethyl-3-fluoropiperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1219832-36-6
• Molecular Formula: C11H21FN2O2
• Molecular Weight: 232.2950432
• Hs Code.: 2933399990
• Mol file: 1219832-36-6.mol

Synonyms:3-AMinoMethyl-3-fluoropiperidine-1-carboxylic acid tert-butyl ester;1-Boc-3-aMinoMethyl-3-fluoropiperidine

Chemical Property of 3-Aminomethyl-3-fluoropiperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 302.4±27.0 °C(Predicted)
• PKA: 10.12±0.29(Predicted)
• PSA: 55.56000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 2.32250

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl3-(Aminomethyl)-3-fluoropiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Aminomethyl-3-fluoropiperidine-1-carboxylic acid tert-butyl ester

There total 3 articles about 3-Aminomethyl-3-fluoropiperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-cyano-3-fluoropiperidine-1-carboxylate (1219832-35-5) → tert-butyl 3-(aminomethyl)-3-fluoro-piperidine-1-carboxylate (1219832-36-6)

Guidance literature:

tert-butyl 3-cyano-3-fluoropiperidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

With Glauber's salt; In tetrahydrofuran; for 0.5h;

Reference yield:

3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) → tert-butyl 3-(aminomethyl)-3-fluoro-piperidine-1-carboxylate (1219832-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water / tetrahydrofuran / 0 °C

1.2: 1 h / 0 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 - 0 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; water; In tetrahydrofuran; dichloromethane;

Reference yield:

tert-butyl 3-cyano-3-hydroxypiperidine-1-carboxylate (1219832-34-4) → tert-butyl 3-(aminomethyl)-3-fluoro-piperidine-1-carboxylate (1219832-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 - 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

tert-butyl 3-cyano-3-fluoropiperidine-1-carboxylate

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-cyano-3-hydroxypiperidine-1-carboxylate

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