4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester
CAS No.:78818-17-4
Molecular Formula:C₁₄H₁₆N₂O₅
Molecular Weight:292.291
Hs Code.:
Mol file:78818-17-4.mol

Synonyms:4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester;

Suppliers and Price of 4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester

Chemical Property:

Boiling Point:548.4±50.0 °C(Predicted)
PKA:3.66±0.10(Predicted)
PSA：87.15000
Density:1.355
LogP:0.42780

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester

There total 1 articles about 4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 78818-17-4
1-carboxymethyl-4-benzyloxycarbonyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / sodium hydrogen carbonate / H₂O / 5 h

2: 1a.) sodium hydride; 3.) 1 N sodium hydroxide / 1a.) DMF, r.t., 1 h; 1b.) 60-70 deg C, 4 h; 2a.) DMF, r.t., 4 h; 2b.) 70-80 deg C, 8 h; 3.) methanol, 30 min

With sodium hydroxide; sodium hydride; sodium hydrogencarbonate; In water;

Reference yield:

: 78818-17-4
1-carboxymethyl-4-benzyloxycarbonyl-2-oxopiperazine

: 78818-18-5
phenylalanylleucine acetate

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 78818-20-9
4-benzyloxycarbonyl-2-oxopiperazin-1-yl-acetylphenylalanylleucine dicyclohexylammonium salt

Guidance literature:: With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) dioxan, r.t., 90 min; 2.) dioxan, water, 2 h; 3.) ether;