tert-Butyl 4-(2,4-difluorobenzoyl)piperidin-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(2,4-difluorobenzoyl)piperidin-1-carboxylate
• CAS No.: 1159825-99-6
• Molecular Formula: C17H21F2NO3
• Molecular Weight: 325.355
• Hs Code.: 2933399090
• Mol file: 1159825-99-6.mol

Synonyms:1-Boc-4-(2,4-Difluorobenzoyl)piperidine;4-(2,4-difluoro-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of tert-Butyl 4-(2,4-difluorobenzoyl)piperidin-1-carboxylate

Chemical Property:

• PSA: 46.61000
• LogP: 3.73250

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(2,4-difluorobenzoyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(2,4-difluorobenzoyl)piperidin-1-carboxylate

There total 1 articles about tert-Butyl 4-(2,4-difluorobenzoyl)piperidin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate (1159825-99-6)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 0 - 30 ℃;

Reference yield: 83.0%

tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate (1159825-99-6) + 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (84163-13-3) → C29H33F2N3O4

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 90 ℃;

Reference yield: 81.0%

tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate (1159825-99-6) + C12H14FN3*ClH (153025-27-5) → C29H34F2N4O3

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 90 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

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