1-(2-Hydroxy-ethyl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 1-(2-Hydroxy-ethyl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS No.: 675843-82-0
• Molecular Formula: C10H12N2O2
• Molecular Weight: 192.21
• Mol file: 675843-82-0.mol

Synonyms:1-(2-hydroxyethyl)-4,6-dimethyl-2-oxopyridine-3-carbonitrile;3-Pyridinecarbonitrile, 1,2-dihydro-1-(2-hydroxyethyl)-4,6-dimethyl-2-oxo-;1-(2-Hydroxy-ethyl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property of 1-(2-Hydroxy-ethyl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-(2-hydroxyethyl)-4,6-dimethyl-2-oxopyridine-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(2-Hydroxy-ethyl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

There total 5 articles about 1-(2-Hydroxy-ethyl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2-acetoxyethyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (748158-63-6) → 4,6-dimethyl-1-(2-hydroxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (675843-82-0)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 24h;

DOI:10.1002/jhet.5570410302

Reference yield: 60.0%

2-cyano-N-(2-hydroxyethyl)acetamide (15029-40-0) + acetylacetone (123-54-6,81235-32-7) → 4,6-dimethyl-1-(2-hydroxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (675843-82-0)

Guidance literature:

With sodium hydroxide; In methanol; water; for 4h; Reflux;

DOI:10.2298/JSC180703092T

Reference yield:

3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) → 4,6-dimethyl-1-(2-hydroxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (675843-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / dimethylformamide / 2 h / 20 °C

1.2: 54 percent / dimethylformamide / 12 h / 20 °C

2.1: 95 percent / aq. ammonia / methanol / 24 h / 20 °C

With ammonium hydroxide; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570410302

upstream raw materials:

1-(2-acetoxyethyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

3-Cyano-4,6-dimethyl-2(1H)-pyridon

4,6-dimethyl-2-(2-hydroxyethoxymethoxy)pyridine-3-carbonitrile

2-[(2-acetoxyethoxymethoxy)]-4,6-dimethylpyridine-3-carbonitrile

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