4-AMINO-2-FLUORO-N-METHYLBENZAMIDE

Base Information

• Chemical Name: 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE
• CAS No.: 915087-25-1
• Molecular Formula: C8H9FN2O
• Molecular Weight: 168.171
• Hs Code.: 2924299090
• Mol file: 915087-25-1.mol

Synonyms:4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;N-Methyl-2-fluoro-4-aminobenzamide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-;2. 4-aMino-2-fluoro-N-MethylbenzaMide

Chemical Property of 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE

Chemical Property:

• Boiling Point: 320℃
• PKA: 14.12±0.46(Predicted)
• Flash Point: 147℃
• PSA: 58.61000
• Density: 1.234
• LogP: 1.92350
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-?Amino-?2-?fluoro-?N-?methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-?Amino-?2-?fluoro-?N-?methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors

Technology Process of 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE

There total 8 articles about 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-4-(4-methoxybenzylamino)-N-methylbenzamide (956104-46-4) → 2-fluoro-N-methyl-4-amino-benzamide (915087-25-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 97.0%

2-fluoro-N-methyl-4-nitro-benzamide (915087-24-0) → 2-fluoro-N-methyl-4-amino-benzamide (915087-25-1)

Guidance literature:

With acetic acid; iron; In ethyl acetate; Reflux;

Reference yield: 72.0%

→ 2-fluoro-N-methyl-4-amino-benzamide (915087-25-1)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 80 - 100 ℃;

upstream raw materials:

2-fluoro-N-methyl-4-nitro-benzamide

2-fluoro-4-(4-methoxybenzylamino)-N-methylbenzamide

2-fluoro-4-nitrobenzoic acid

2-fluoro-4-nitrotoluene

Downstream raw materials:

4-(1-cyano-cyclobutanylamino)-2-fluoro-N-methyl-benzamide

N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide

4-[7-(2-chloro-4-cyano-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

4-[7-(4-cyano-3-methoxy-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide