Heptanamide, 3-amino-N-cyclopropyl-2-hydroxy-, (Hydrochloride) (1:1), (3S)-

Base Information

• Chemical Name: Heptanamide, 3-amino-N-cyclopropyl-2-hydroxy-, (Hydrochloride) (1:1), (3S)-
• CAS No.: 1137141-25-3
• Molecular Formula: C10H21ClN2O2
• Molecular Weight: 236.742
• Mol file: 1137141-25-3.mol

Synonyms:(S)-3-amino-2-hydroxy-heptanoic acid cyclopropylamide hydrochloride salt;(S)-3-amino-1-chloro-4-phenyl-2-butanone,hydrogen bromide;(S)-3-acetoacetoxy-1-benzylpyrrolidine;(3S)-3-Oxo-butanoic acid 1-(phenylmethyl)-3-pyrrolidinyl ester;

Chemical Property of Heptanamide, 3-amino-N-cyclopropyl-2-hydroxy-, (Hydrochloride) (1:1), (3S)-

Chemical Property:

• PSA: 78.84000
• LogP: 2.48600

Purity/Quality:

99% ^*data from raw suppliers

Heptanamide,3-amino-N-cyclopropyl-2-hydroxy-,(Hydrochloride)(1:1),(3S)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Heptanamide, 3-amino-N-cyclopropyl-2-hydroxy-, (Hydrochloride) (1:1), (3S)-

There total 2 articles about Heptanamide, 3-amino-N-cyclopropyl-2-hydroxy-, (Hydrochloride) (1:1), (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H28N2O4 → (S)-3-amino-2-hydroxy-heptanoic acid cyclopropylamide hydrochloride salt (1137141-25-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2010.01.044

Reference yield:

C17H30N2O5 (1208245-72-0) → (S)-3-amino-2-hydroxy-heptanoic acid cyclopropylamide hydrochloride salt (1137141-25-3)

Guidance literature:

C₁₇H₃₀N₂O₅; With water; lithium hydroxide; In tetrahydrofuran;

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/ml9000276

Reference yield:

(S)-3-amino-2-hydroxy-heptanoic acid cyclopropylamide hydrochloride salt (1137141-25-3) + C24H39N3O6S (865469-66-5) → C34H57N5O7S (865469-67-6)

Guidance literature:

With 4-methyl-morpholine; HATU; In DMF (N,N-dimethyl-formamide); dichloromethane; at 0 - 25 ℃;

upstream raw materials:

C₁₇H₃₀N₂O₅

Downstream raw materials:

C₃₄H₅₇N₅O₇S

C₃₅H₅₉N₅O₇S

C₃₆H₆₃N₅O₇S

Refernces

• 1、 Arasappan, Ashok,Bennett, Frank,Bogen, Stephane L.,Venkatraman, Srikanth,Blackman, Melissa,Chen, Kevin X.,Hendrata, Siska,Huang, Yuhua,Huelgas, Regina M.,Nair, Latha,Padilla, Angela I.,Pan, Weidong,Pike, Russell,Pinto, Patrick,Ruan, Sumei,Sannigrahi, Mousumi,Velazquez, Francisco,Vibulbhan, Bancha,Wu, Wanli,Yang, Weiying,Saksena, Anil K.,Girijavallabhan, Viyyoor,Shih, Neng-Yang,Kong, Jianshe,Meng, Tao,Jin, Yan,Wong, Jesse,McNamkra, Paul,Prongay, Andrew,Madison, Vincent,Piwinski, John J.,Cheng, Kuo-Chi,Morrison, Richard,Malcolm, Bruce,Tong, Xiao,Ralston, Robert,Njoroge, F. George. "Discovery of narlaprevir (SCH 900518): A potent, second generation HCV NS3 serine protease inhibitor". scheme or table. p. 64 - 69. Retrieved 2010/12/29.