2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid

Base Information

• Chemical Name: 2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid
• CAS No.: 127733-45-3
• Molecular Formula: C17H13F3O4
• Molecular Weight: 338.283
• Mol file: 127733-45-3.mol

Synonyms:2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid;

Chemical Property of 2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid

Chemical Property:

• PSA: 63.60000
• LogP: 4.32160

Purity/Quality:

≥95% ^*data from raw suppliers

2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid

There total 3 articles about 2-((1-(2-(trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) + C9H8F3O(1-)*Cl(1-)*Mg(2+) (934226-13-8) → (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl acid phthalate (127733-45-3)

Guidance literature:

phthalic anhydride; C₉H₈F₃O^(1-)*Cl^(1-)*Mg⁽²⁺⁾; In tetrahydrofuran; at 9 - 37 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

phthalic anhydride (85-44-9) + (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol (79756-81-3) → (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl acid phthalate (127733-45-3)

Guidance literature:

With pyridine; 1.) RT, 24 h, 2.) 90 deg C, 6 h;

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) → (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl acid phthalate (127733-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / tetrahydrofuran / 1 h / Ambient temperature

2: pyridine / 1.) RT, 24 h, 2.) 90 deg C, 6 h

With pyridine; In tetrahydrofuran;

upstream raw materials:

phthalic anhydride

(+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol

2-Trifluoromethylbenzaldehyde

C₉H₈F₃O^(1-)*Cl^(1-)*Mg⁽²⁺⁾

Downstream raw materials:

(S)-1-(2-trifluoromethylphenyl)ethanol

(S)-1-(2-(trifluoromethyl)phenyl)ethanol

(S)-1-(2-trifluoromethylphenyl)ethyl alcohol phthalate half ester-(S)-1-phenylethylamine