PF-3084014

Base Information

Chemical Name:PF-3084014
CAS No.:1290543-63-3
Molecular Formula:C27H41F2N5O
Molecular Weight:489.64
Hs Code.:29332900

Synonyms:Nirogacestat;CS-2699;PF-3084014;PF-03084014 (PF-3084014);Nirogacestat (PF-03084014;PF-03084014 (Nirogacestat);PF03084014;PF 03084014;PF-03084014;Nirogacestat(PF-03084014,PF-3084014);(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide;Pentanamide, 2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-, (2S)-

Suppliers and Price of PF-3084014

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
PF-03084014(Nirogacestat) >98%
100 mg
$ 850.00

DC Chemicals
PF-03084014(Nirogacestat) >98%
250 mg
$ 1600.00

CSNpharm
PF-3084014
1mg
$ 49.00

Crysdot
PF-3084014 98+%
10mg
$ 216.00

Crysdot
PF-3084014 98+%
50mg
$ 863.00

Crysdot
PF-3084014 98+%
25mg
$ 455.00

ChemScene
Nirogacestat 99.95%
50mg
$ 600.00

ChemScene
Nirogacestat 99.95%
100mg
$ 1000.00

ChemScene
Nirogacestat 99.95%
10mg
$ 150.00

ChemScene
Nirogacestat 99.95%
5mg
$ 90.00

Total 16 raw suppliers

Chemical Property of PF-3084014

Chemical Property:

PSA：74.47000
LogP:6.21770
Storage Temp.:room temp

Purity/Quality:

99%, ^*data from raw suppliers

PF-03084014(Nirogacestat) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of PF-3084014

There total 9 articles about PF-3084014 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865774-07-8
2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester

: 1290543-63-3,865773-15-5
PF-03084014

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / dichloromethane / -30 °C

2: dichloromethane / Molecular sieve

3: sodium tris(acetoxy)borohydride

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

5: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

: 865774-76-1
2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde

: 1290543-63-3,865773-15-5
PF-03084014

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / Molecular sieve

2: sodium tris(acetoxy)borohydride

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

4: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

: 843644-23-5
6,8-difluoro-3,4-dihydronaphthalen-2(1H)-one

: 1290543-63-3,865773-15-5
PF-03084014

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane

2: hydrogenchloride; water

3: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.118