5-(3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide

Base Information

Chemical Name:5-(3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide
CAS No.:1089278-50-1
Molecular Formula:C25H16ClF2N5O2
Molecular Weight:491.884
Hs Code.:
Mol file:1089278-50-1.mol

Synonyms:5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide;5-[3-(2,3-dichloro-phenoxy)-propyl]-pyrimidine-2,4,6-triamine;

Suppliers and Price of 5-(3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
5-(3-(2-Chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide 95%+
1g
$ 2360.00

Chemenu
5-(3-(2-Chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide 95%+
250mg
$ 1022.00

Total 8 raw suppliers

Chemical Property of 5-(3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide

Chemical Property:

PKA:11.11±0.70(Predicted)
PSA：84.90000
Density:1.44±0.1 g/cm3(Predicted)
LogP:6.03480

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-(3-(2-Chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-(3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide

There total 1 articles about 5-(3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 504-29-0
2-aminopyridine

: 1089278-52-3
5-[(2-Chloro-4-pyrimidinyl)acetyl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide

: 1089278-50-1
5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide

Guidance literature:: 5-[(2-Chloro-4-pyrimidinyl)acetyl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide; With N-Bromosuccinimide; In dichloromethane; for 0.333333h;

2-aminopyridine; In 1,4-dioxane; dichloromethane; at 20 - 60 ℃; for 64h;

With sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;

Reference yield: 68.0%

: 1089281-31-1
2-(methyloxy)-4-[2-(4-methyl-1-piperazinyl)ethyl]aniline

: 1089278-50-1
5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide

: 1089281-29-7
N-(2,6-difluorophenyl)-2-(methyloxy)-5-{3-[2-({2-(methyloxy)-4-[2-(4-methyl-1-piperazinyl)ethyl]phenyl}amino)-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl}benzamide

Guidance literature:: 2-(methyloxy)-4-[2-(4-methyl-1-piperazinyl)ethyl]aniline; 5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide; With toluene-4-sulfonic acid; In isopropyl alcohol; at 180 ℃; for 0.283333h; microwave irradiation;

With sodium methylate; In isopropyl alcohol;

Reference yield: 68.0%

: 1089281-42-4
2-(methyloxy)-4-(1-propyl-4-piperidinyl)aniline

: 1089278-50-1
5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide

: 1089281-39-9
N-(2,6-difluorophenyl)-2-(methyloxy)-5-[3-(2-{[2-(methyloxy)-4-(1-propyl-4-piperidinyl)phenyl]amino}-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]benzamide

Guidance literature:: 2-(methyloxy)-4-(1-propyl-4-piperidinyl)aniline; 5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide; With toluene-4-sulfonic acid; In isopropyl alcohol; at 120 ℃; for 24h;

With sodium methylate; In isopropyl alcohol;