methyl 5-amino-2-methoxy-4-methylbenzoate

Base Information

• Chemical Name: methyl 5-amino-2-methoxy-4-methylbenzoate
• CAS No.: 70752-21-5
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.22
• Hs Code.: 2922500090
• Mol file: 70752-21-5.mol

Synonyms:methyl 2-methoxy-4-methyl-5-aminobenzoate;methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate;

Chemical Property of methyl 5-amino-2-methoxy-4-methylbenzoate

Chemical Property:

• PSA: 61.55000
• LogP: 1.95360

Purity/Quality:

≥95% ^*data from raw suppliers

methyl5-amino-2-methoxy-4-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-amino-2-methoxy-4-methylbenzoate

There total 3 articles about methyl 5-amino-2-methoxy-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-methoxy-4-methyl-5-nitrobenzoate (1057652-79-5) → methyl 2-methoxy-4-methyl-5-aminobenzoate (70752-21-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1021/jm00375a009

Reference yield:

2-methoxy-4-methyl-5-nitrobenzoic acid (90763-12-5) → methyl 2-methoxy-4-methyl-5-aminobenzoate (70752-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 1 h / Heating

3: 2.38 g / H₂ / PtO₂ / methanol

With thionyl chloride; hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1021/jm00375a009

Reference yield:

2-methoxy-4-methyl-5-nitrobenzoyl chloride (68256-33-7) → methyl 2-methoxy-4-methyl-5-aminobenzoate (70752-21-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 2.38 g / H₂ / PtO₂ / methanol

With hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1021/jm00375a009

upstream raw materials:

methyl 2-methoxy-4-methyl-5-nitrobenzoate

2-methoxy-4-methyl-5-nitrobenzoic acid

2-methoxy-4-methyl-5-nitrobenzoyl chloride

Downstream raw materials:

methyl 2-methoxy-4-methyl-5-methanesulfonamidobenzoate

methyl 2-methoxy-4-methyl-5-<(dimethylsulfamoyl)amino>benzoate

N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-methyl-5-<(dimethylsulfamoyl)methylamino>benzamide

N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-(N-methylmethanesulfonamido)benzamide