1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone
CAS No.:439578-98-0
Molecular Formula:C18H22N4O3S2
Molecular Weight:406.53
Hs Code.:
Mol file:439578-98-0.mol

Synonyms:1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone;Ethanone, 1-[4-[5-[(2-amino-5-thiazolyl)thio]-2-methoxy-4-methylbenzoyl]-1-piperazinyl]-;1-(4-(5-((2-aminothiazol-5-yl)thio)-2-methoxy-4-methylbenzoyl)piperazin-1-yl)ethan-1-one

Suppliers and Price of 1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
1-(4-(5-(2-Aminothiazol-5-ylthio)-2-methoxy-4-methylbenzoyl)piperazin-1-yl)ethanone 95%+
250mg
$ 1245.00

Chemenu
1-(4-(5-(2-Aminothiazol-5-ylthio)-2-methoxy-4-methylbenzoyl)piperazin-1-yl)ethanone 95%+
100mg
$ 934.00

Total 7 raw suppliers

Chemical Property of 1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone

Chemical Property:

PSA：143.03000
LogP:2.30370

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(4-(5-(2-Aminothiazol-5-ylthio)-2-methoxy-4-methylbenzoyl)piperazin-1-yl)ethanone 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone

There total 6 articles about 1-(4-(5-(2-aMinothiazol-5-ylthio)-2-Methoxy-4-Methylbenzoyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 439578-97-9
5-(2-aminothiazol-5-yl)sulfanyl-2-methoxy-4-methylbenzoic acid

: 13889-98-0
N-acetylpiperidine

: 439578-98-0
1-{4-[5-(2-amino-thiazol-5-ylsulfanyl)-2-methoxy-4-methyl-benzoyl]-piperazin-1-yl}-ethanone

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.04.060

Reference yield:

: 439579-12-1
5-mercapto-2-methoxy-4-methylbenzoic acid

: 439578-98-0
1-{4-[5-(2-amino-thiazol-5-ylsulfanyl)-2-methoxy-4-methyl-benzoyl]-piperazin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaOMe / methanol / 0 - 20 °C

2: 78 percent / EDAC; HOAt; i-Pr₂NEt / tetrahydrofuran

With 1-hydroxy-7-aza-benzotriazole; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2006.04.060

Reference yield:

: 439579-02-9
2-Amino-5-[(5-carbomethoxy-4-methoxy-2-methylphenyl)thio]thiazole

: 439578-98-0
1-{4-[5-(2-amino-thiazol-5-ylsulfanyl)-2-methoxy-4-methyl-benzoyl]-piperazin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP / tetrahydrofuran

2: aq. NaOH / methanol

3: EDAC; HOAt; i-Pr₂NEt / tetrahydrofuran

4: TFA

With dmap; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2006.04.060