2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1)

Base Information

Chemical Name:2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1)
CAS No.:435345-04-3
Molecular Formula:C7H8F2N2.C6H6O3S
Molecular Weight:316.3236664
Hs Code.:
Mol file:435345-04-3.mol

Synonyms:2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1;2,2-difluoro-2-(pyridin-2-yl)ethanamine benzenesulfonate;2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1);2,2-Difluoro-2-pyridin-2-yl-ethylamine benzene sulfonate salt

Suppliers and Price of 2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
2,2-difluoro-2-(pyridin-2-yl)ethanaminebenzenesulfonate
1g
$ 970.40

Total 5 raw suppliers

Chemical Property of 2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1)

Chemical Property:

PSA：101.66000
LogP:3.84650

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,2-difluoro-2-(pyridin-2-yl)ethanaminebenzenesulfonate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1)

There total 6 articles about 2-PyridineethanaMine, b,b-difluoro-, benzenesulfonate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₁₄H₁₃F₄N₃

: 98-11-3
benzenesulfonic acid

: 267875-68-3
2.2-Difluoro-2-(pyridin-2-yl)ethylamine

: 435345-04-3
2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt

Guidance literature:: In Isopropyl acetate; at 5 - 10 ℃; for 1.33333h; Inert atmosphere; Large scale;
DOI:10.1021/op0341420

Reference yield: 49.5%

: 1299945-50-8
2,2-difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate

: 98-11-3
benzenesulfonic acid

: 435345-04-3
2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt

Guidance literature:: 2,2-difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate; With ammonia; sodium iodide; In water; dimethyl sulfoxide; at 80 ℃; for 40h;

benzenesulfonic acid; In dichloromethane; Isopropyl acetate; at 20 ℃; for 1h;

Reference yield:

: 109-04-6
2-bromo-pyridine

: 435345-04-3
2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper / N,N-dimethyl-formamide / 0.75 h / 70 - 80 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 1.5 h / 0 - 10 °C

3.1: triethylamine / dichloromethane / 25 h / 0 - 20 °C

4.1: sodium iodide; ammonia / water; dimethyl sulfoxide / 40 h / 80 °C

4.2: 1 h / 20 °C

With sodium tetrahydroborate; ammonia; copper; triethylamine; sodium iodide; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;