Chemical Property of Wnt-C59
Chemical Property:
- Boiling Point:628.3±55.0 °C(Predicted)
- PKA:13.78±0.70(Predicted)
- PSA：54.88000
- Density:1.198±0.06 g/cm3(Predicted)
- LogP:5.37320
- Storage Temp.:+2C to +8C
- Solubility.:Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
- Purity/Quality:
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99%, *data from raw suppliers
Wnt-C59 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
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Uses
Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
