GS9620

Base Information

Chemical Name:GS9620
CAS No.:1228585-88-3
Molecular Formula:C22H30N6O2
Molecular Weight:410.519
Hs Code.:
Mol file:1228585-88-3.mol

Synonyms:CS-1352;4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one;UNII-O8M467C50G;4-amino-2-n-butoxy-8-[3'-(pyrrolidin-1"-ylmethyl)-benzyl]-5,6,7,8-tetrahydropteridin-6-one;GS-9620;8-(3-(pyrrolidin-1-ylmethyl)benzyl)-4-amino-2-butoxy-7,8-dihydropteridin-6(5H)-one;

Suppliers and Price of GS9620

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GS-9620(Vesatolimod) >98%
1 g
$ 1700.00

DC Chemicals
GS-9620(Vesatolimod) >98%
250 mg
$ 800.00

Crysdot
GS-9620 98+%
25mg
$ 237.00

Crysdot
GS-9620 98+%
50mg
$ 379.00

Crysdot
GS-9620 98+%
100mg
$ 548.00

ChemScene
Vesatolimod 99.90%
100mg
$ 440.00

ChemScene
Vesatolimod 99.90%
50mg
$ 270.00

ChemScene
Vesatolimod 99.90%
25mg
$ 190.00

ChemScene
Vesatolimod 99.90%
5mg
$ 50.00

ChemScene
Vesatolimod 99.90%
10mg
$ 95.00

Total 34 raw suppliers

Chemical Property of GS9620

Chemical Property:

PKA:10.34±0.20(Predicted)
PSA：100.10000
Density:1.247±0.06 g/cm3(Predicted)
LogP:3.46140
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (10 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

GS-9620(Vesatolimod) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expressionex vivoin latently-infected peripheral blood mononuclear cells (PBMCs) from virally suppressed patients. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients.

Technology Process of GS9620

There total 7 articles about GS9620 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)acetate hydrochloride

: 1228585-88-3
4-amino-2-n-butoxy-8-[3’-(pyrrolidin-1“-ylmethyl)-benzyl]-5,6,7,8-tetrahydropteridin-6-one

Guidance literature:: ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)acetate hydrochloride; With acetic acid; In water; at 20 ℃; for 0.25h;

With zinc; In water; at 20 - 40 ℃; for 0.16h;

Reference yield:

: 1228588-13-3
ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)acetate

: 1228585-88-3
4-amino-2-n-butoxy-8-[3’-(pyrrolidin-1“-ylmethyl)-benzyl]-5,6,7,8-tetrahydropteridin-6-one

Guidance literature:: With hydrogen; In methanol; water; for 1.5h;

Reference yield:

: 1228587-56-1
ethyl 2-((6-amino-2-(methylthio)-5-nitropyrimidin-4-yl)(3-(pyrrolidin-1-ylmethyl)benzyl)amino)acetate

: 1228585-88-3
4-amino-2-n-butoxy-8-[3’-(pyrrolidin-1“-ylmethyl)-benzyl]-5,6,7,8-tetrahydropteridin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tungstate (VI) dihydrate; acetic acid; dihydrogen peroxide / water; ethanol / 19 h / 0 °C

2.1: trifluoroacetic acid / 1 h / 100 °C

3.1: hydrogen / methanol / 1.5 h

3.2: pH 1-2

With sodium tungstate (VI) dihydrate; hydrogen; dihydrogen peroxide; acetic acid; trifluoroacetic acid; In methanol; ethanol; water;