HOE-33187

Base Information

• Chemical Name: HOE-33187
• CAS No.: 23623-08-7
• Molecular Formula: C25H24N6
• Molecular Weight: 408.5
• Mol file: 23623-08-7.mol

Synonyms:CS-1308;2'-phenyl-5-(4-methylpiperazinyl)-2,5'-bi-1H-benzimidazole;5-(4-methyl-piperazin-1-yl)-2'-phenyl-1H,1'H-[2,5']bibenzoimidazolyl;

Chemical Property of HOE-33187

Chemical Property:

• PSA: 63.84000
• LogP: 4.52790

Purity/Quality:

97% ^*data from raw suppliers

HOE33187 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HOE-33187

There total 8 articles about HOE-33187 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-phenyl-5-formylbenzimidazole (174648-21-6) + 4-(4-methylpiperazino)-1,2-diaminobenzene (54998-08-2) → 2'-phenyl-5-(4-methylpiperazinyl)-2,5'-bi-1H-benzimidazole (23623-08-7)

Guidance literature:

In nitrobenzene; at 145 ℃;

DOI:10.1021/jm950412w

Reference yield:

1-methyl-piperazine (109-01-3) → 2'-phenyl-5-(4-methylpiperazinyl)-2,5'-bi-1H-benzimidazole (23623-08-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 18 h / 120 °C

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h / 2327.2 Torr

3: 31 percent / nitrobenzene / 145 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; nitrobenzene; N,N-dimethyl-formamide;

DOI:10.1021/jm950412w

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 2'-phenyl-5-(4-methylpiperazinyl)-2,5'-bi-1H-benzimidazole (23623-08-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 18 h / 120 °C

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h / 2327.2 Torr

3: 31 percent / nitrobenzene / 145 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; nitrobenzene; N,N-dimethyl-formamide;

DOI:10.1021/jm950412w

upstream raw materials:

2-phenyl-5-formylbenzimidazole

4-(4-methylpiperazino)-1,2-diaminobenzene

1-methyl-piperazine

5-chloro-2-nitroaniline