M2 ion channel blocker

Base Information

• Chemical Name: M2 ion channel blocker
• CAS No.: 1190215-03-2
• Molecular Formula: C18H27N3O2
• Molecular Weight: 317.43
• Mol file: 1190215-03-2.mol

Synonyms:M2 ion channel blocker;CS-0770;

Chemical Property of M2 ion channel blocker

Chemical Property:

• Boiling Point: 511.7±40.0 °C(Predicted)
• PKA: 13.77±0.10(Predicted)
• PSA: 63.05000
• Density: 1.192±0.06 g/cm3(Predicted)
• LogP: 1.85600

Purity/Quality:

95% ^*data from raw suppliers

M2ionchannelblocker 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of M2 ion channel blocker

There total 2 articles about M2 ion channel blocker which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ 2-[(adamantan-1-ylmethyl)amino]-3-(3H-imidazol-4-yl)propionic acid methyl ester (1190215-03-2)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; Inert atmosphere;

Reference yield: 31.0%

1-Adamantanecarbaldehyde (2094-74-8) + L-histidine methyl ester (1499-46-3,10331-70-1,17720-12-6,62013-45-0) → 2-[(adamantan-1-ylmethyl)amino]-3-(3H-imidazol-4-yl)propionic acid methyl ester (1190215-03-2)

Guidance literature:

1-Adamantanecarbaldehyde; L-histidine methyl ester; In methanol; at 20 ℃; for 1.5h;

With sodium cyanoborohydride; In methanol; at 0 ℃;

DOI:10.1002/cjoc.201090242

upstream raw materials:

1-Adamantanecarbaldehyde

L-histidine methyl ester

Refernces

• 1、 Zhang, Wenjuan,Xu, Jing,Liu, Fang,Li, Chufang,Jie, Yanling,Chen, Shaopeng,Li, Zhiyuan,Liu, Jinsong,Chen, Ling,Zhou, Guochun. "Heterodimers of histidine and amantadine as inhibitors for wild type and mutant M2 channels of influenza A". experimental part. p. 1417 - 1423. Retrieved 2011/01/04.