2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Base Information

Chemical Name:2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
CAS No.:23554-98-5
Molecular Formula:C26H26N6
Molecular Weight:422.52
Hs Code.:
DSSTox Substance ID:DTXSID30435164
Nikkaji Number:J721.003E
ChEMBL ID:CHEMBL177795
Mol file:23554-98-5.mol

Synonyms:23554-98-5;2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole;CS-1313;CHEMBL177795;SCHEMBL19484925;DTXSID30435164;YAA55498;HY-15625;MS-27423;PD101465;F84927;A912885;2'-(4-Methylphenyl)-5-(4-methylpiperazin-1-yl)-2,6'-bi[1H-benzimidazole];6-(4-Methylpiperazin-1-yl)-2'-(p-tolyl)-1H,3'H-2,5'-bibenzo[d]imidazole

Suppliers and Price of 2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Hoechst33258analog3 98+%
100mg
$ 224.00

Crysdot
Hoechst33258analog3 98+%
50mg
$ 168.00

Total 8 raw suppliers

Chemical Property of 2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Chemical Property:

PSA：63.84000
LogP:4.83630
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:422.22189485
Heavy Atom Count:32
Complexity:628

Purity/Quality:

97% ^*data from raw suppliers

Hoechst33258analog3 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C

Technology Process of 2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

There total 8 articles about 2-(4-methylphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 174648-27-2
2-p-tolyl-5-formylbenzimidazole

: 54998-08-2
4-(4-methylpiperazino)-1,2-diaminobenzene

: 23554-98-5
2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole

Guidance literature:: In nitrobenzene; at 145 ℃;
DOI:10.1021/jm950412w

Reference yield:

: 109-01-3
1-methyl-piperazine

: 23554-98-5
2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 18 h / 120 °C

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h / 2327.2 Torr

3: 85 percent / nitrobenzene / 145 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1021/jm950412w

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 23554-98-5
2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 18 h / 120 °C

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h / 2327.2 Torr

3: 85 percent / nitrobenzene / 145 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1021/jm950412w