(1R,3aR,7aR)-1-((2R,5S)-5,6-dimethylheptan-2-yl)-7a-methyloctahydro-1H-inden-4-ol

Base Information

• Chemical Name: (1R,3aR,7aR)-1-((2R,5S)-5,6-dimethylheptan-2-yl)-7a-methyloctahydro-1H-inden-4-ol
• CAS No.: 33813-75-1
• Molecular Formula: C19H36O
• Molecular Weight: 280.49
• Mol file: 33813-75-1.mol

Synonyms:(1R,3aR,4S,7aR)-7a-methyl-1-[(1R,4S)-1,4,5-trimethylhexyl]octahydro-1H-inden-4-ol;Des-AB-ergostan-8β-ol;(1R,3aR,4S,7aR)-7a-Methyl-1-((1R,4S)-1,4,5-trimethyl-hexyl)-octahydro-inden-4-ol;(1R,3aR,4S,7aR,1'R,4'S)-hexahydro-7a-methyl-1-(1',4',5'-trimethylhexyl)-indan-4-ol;

Chemical Property of (1R,3aR,7aR)-1-((2R,5S)-5,6-dimethylheptan-2-yl)-7a-methyloctahydro-1H-inden-4-ol

Chemical Property:

• Boiling Point: 338.6±10.0 °C(Predicted)
• PKA: 15.07±0.60(Predicted)
• PSA: 20.23000
• Density: 0.921±0.06 g/cm3(Predicted)
• LogP: 5.27210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,3aR,7aR)-1-((2R,5S)-5,6-dimethylheptan-2-yl)-7a-methyloctahydro-1H-inden-4-ol

There total 6 articles about (1R,3aR,7aR)-1-((2R,5S)-5,6-dimethylheptan-2-yl)-7a-methyloctahydro-1H-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3aR,4S,7aR)-7a-methyl-1-<(2E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl>-octahydro-1H-inden-4-ol (55812-82-3,63730-57-4,63730-58-5,102281-42-5) → (1R,3aR,4S,7aR)-7a-methyl-1-<(1R,4S)-1,4,5-trimethylhexyl>-octahydro-1H-inden-4-ol (33813-75-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h;

Reference yield:

Calciferol (50-14-6) → (1R,3aR,4S,7aR)-7a-methyl-1-<(1R,4S)-1,4,5-trimethylhexyl>-octahydro-1H-inden-4-ol (33813-75-1)

Guidance literature:

Multi-step reaction with 4 steps

1: KMnO₄

3: 1.) Pb(OAc)4, pyridine, 2.) NaBH₄, CeCl₃*7H₂O / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₃OH, 0 deg C, 3 h

4: 1.80 g / H₂ / Pd/C / methanol / 16 h

With pyridine; lead(IV) acetate; sodium tetrahydroborate; potassium permanganate; cerium(III) chloride; hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

(4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol (84985-78-4) → (1R,3aR,4S,7aR)-7a-methyl-1-<(1R,4S)-1,4,5-trimethylhexyl>-octahydro-1H-inden-4-ol (33813-75-1)

Guidance literature:

Multi-step reaction with 3 steps

2: 1.) Pb(OAc)4, pyridine, 2.) NaBH₄, CeCl₃*7H₂O / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₃OH, 0 deg C, 3 h

3: 1.80 g / H₂ / Pd/C / methanol / 16 h

With pyridine; lead(IV) acetate; sodium tetrahydroborate; cerium(III) chloride; hydrogen; palladium on activated charcoal; In methanol;

upstream raw materials:

(1R,3aR,4S,7aR)-7a-methyl-1-<(2E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl>-octahydro-1H-inden-4-ol

Calciferol

(4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol

(5Z,22E)-(7R)-3β-(tert-butyldimethylsilyloxy)-9,10-seco-8α-ergosta-5,10(19),22-triene-7,8-diol

Downstream raw materials:

(1R,3aR,7aR,1'R,4'S)-5,6,7,7a-tetrahydro-7a-methyl-1-(1',4',5'-trimethylhexyl)-3aH-indan-4-one

(3R,3aR)-3a-methyl-7-phenylsulfonyl-3-<(1R,4S)-1,4,5-trimethyl-hexyl>-2,3,3a,4,5,6-hexahydro-1H-indene

(3R,3aR)-3a-methyl-7-phenylsulfanyl-3-<(1R,4S)-1,4,5-trimethyl-hexyl>-2,3,3a,4,5,6-hexahydro-1H-indene

(1R,3aR,4S,7aR)-4-benzenesulfonyl-7a-methyl-1-<(1R,4S)-1,4,5-trimethyl-hexyl>-octahydroindene