BMN 673 (8R,9S)

Base Information

Chemical Name:BMN 673 (8R,9S)
CAS No.:1207456-00-5
Molecular Formula:C19H14F2N6O
Molecular Weight:380.357
Hs Code.:
Mol file:1207456-00-5.mol

Synonyms:(8R,9S)-BMN-673;BMN 673 (8R,9S);BMN673 (8R,9S);BMN-673 (8R,9S);(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one;(8R,9S)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one

Suppliers and Price of BMN 673 (8R,9S)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 97%
50mg
$ 1530.00

Matrix Scientific
(8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 97%
200mg
$ 3600.00

DC Chemicals
BMN-6738R,9S >95%，ee>92%
1 g
$ 2100.00

DC Chemicals
BMN-6738R,9S >95%，ee>92%
100 mg
$ 600.00

Crysdot
BMN-6738R,9S 98+%
50mg
$ 455.00

Crysdot
BMN-6738R,9S 98+%
100mg
$ 770.00

Crysdot
BMN-6738R,9S 98+%
10mg
$ 186.00

Crysdot
BMN-6738R,9S 98+%
5mg
$ 109.00

ChemScene
(8R,9S)-Talazoparib 95.08%
5mg
$ 350.00

ChemScene
(8R,9S)-Talazoparib 95.08%
1mg
$ 280.00

Total 14 raw suppliers

Chemical Property of BMN 673 (8R,9S)

Chemical Property:

PKA:10.14±0.60(Predicted)
PSA：91.98000
Density:1.63±0.1 g/cm3(Predicted)
LogP:1.89830
Solubility.:≥38 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥15.03 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

97% ^*data from raw suppliers

(8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of BMN 673 (8R,9S)

There total 20 articles about BMN 673 (8R,9S) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1207454-56-5
5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

: 1207456-01-6
((11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5⁽¹³⁾,6,8-tetraen-4-one)

: 1207456-00-5
(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one

Guidance literature:: With CHIRALPAK IA; In methanol; diethylamine; Resolution of racemate;

Reference yield: 55.0%

: (2R,3R)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

: 1207456-00-5
(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 2h;

Reference yield:

: 1207453-90-4
6-fluoro-4-nitroisobenzofuran-1(3H)-one

: 1207456-01-6
((11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5⁽¹³⁾,6,8-tetraen-4-one)

: 1207456-00-5
(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride; triethylamine / dichloromethane; 2-methyltetrahydrofuran / 20 - 95 °C / Industry scale

2: hydrogenchloride / methanol / 25 h / 20 °C

3: hydrogenchloride; titanium(III) chloride / water; tetrahydrofuran; methanol

4: hydrazine hydrate / methanol / 20 °C

5: CHIRALPAK IA column / diethylamine; carbon dioxide; methanol / Resolution of racemate

With hydrogenchloride; titanium(III) chloride; acetic anhydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; dichloromethane; carbon dioxide; water; diethylamine;