BMS 927711

Base Information Edit

Chemical Name:BMS 927711
CAS No.:1289023-67-1
Molecular Formula:C28H28F2N6O3
Molecular Weight:534.566
Hs Code.:
Mol file:1289023-67-1.mol

Synonyms:(5S,6S,9R)-5-nitro-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;

Suppliers and Price of BMS 927711

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Rimegepant
500mg
$ 15225.00

Medical Isotopes, Inc.
Rimegepant
1 mg
$ 290.00

DC Chemicals
BMS-927711(Rimegepant) >98%
250 mg
$ 1500.00

Crysdot
BMS-927711 98+%
10mg
$ 282.00

Crysdot
BMS-927711 98+%
5mg
$ 176.00

Crysdot
BMS-927711 98+%
100mg
$ 1367.00

Crysdot
BMS-927711 98+%
50mg
$ 977.00

ChemScene
Rimegepant 99.08%
50mg
$ 750.00

ChemScene
Rimegepant 99.08%
5mg
$ 140.00

ChemScene
Rimegepant 99.08%
10mg
$ 240.00

Total 35 raw suppliers

Chemical Property of BMS 927711 Edit

Chemical Property:

PKA:12.03±0.20(Predicted)
PSA：119.39000
Density:1.45±0.1 g/cm3(Predicted)
LogP:5.54050
Solubility.:Soluble in DMSO

Purity/Quality:

99% ^*data from raw suppliers

Rimegepant ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Rimegepant (Nurtec ODT)(FDA approved in February 2020) is an ODT available in a single strength of 75 mg for the acute treatment of migraine with or without aura in adults.No more than 75 mg should be taken in a 24-hour period. while there are no contraindications，concomitant administration with CYP3A4 inhibitors should be avoided.The most common adverse reaction is nausea, occurring in few patients (rimegepant PI, 2020). In clinical trials, a single 75-mg dose of rimegepant demonstrated superiority over placebo with regard to freedom from pain (21% in the rimegepant group vs.11% in the placebo group) and freedom from the most bothersome symptom (35% vs. 27%) at 2 hours post dose (Croop et al., 2019). Rimegepant is not approved for migraine prevention, although it is presently in late-stage clinical trials assessing it for that indication(NCT03732638,2020).

Technology Process of BMS 927711

There total 11 articles about BMS 927711 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1289023-63-7
(5S,6S,9R)-5-azido-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

: 1289023-67-1
BMS-927711

Guidance literature:: (5S,6S,9R)-5-azido-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-1-yl)piperidine-1-carboxylate; With trimethylphosphane; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

With water; In tetrahydrofuran; toluene; for 3h;

Reference yield: 78.3%

: 1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one

: (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol dihydrochloride

: 1289023-67-1
BMS-927711

Guidance literature:: (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol dihydrochloride; With water; sodium carbonate; sodium chloride; for 0.5h;

1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one; With potassium 2,2-dimethyl-1-propanolate; In tetrahydrofuran; at 20 ℃;

With citric acid; sodium chloride; In tetrahydrofuran; water;