GDC-0623

Base Information

Chemical Name:GDC-0623
CAS No.:1168091-68-6
Molecular Formula:C16H14FIN4O3
Molecular Weight:456.215
Hs Code.:
Mol file:1168091-68-6.mol

Synonyms:5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide;5-(2-fluoro-4-iodophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxyethoxy)-amide;GDC 0623;5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide;

Suppliers and Price of GDC-0623

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GDC 0623
100mg
$ 2272.00

DC Chemicals
GDC-0623 >98%
1 g
$ 2500.00

Crysdot
GDC-0623 98+%
10mg
$ 278.00

Crysdot
GDC-0623 98+%
100mg
$ 926.00

Crysdot
GDC-0623 98+%
50mg
$ 687.00

Chemenu
5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide 98%
100mg
$ 439.00

Cayman Chemical
GDC-0623 ≥98%
5mg
$ 99.00

Cayman Chemical
GDC-0623 ≥98%
1mg
$ 33.00

Cayman Chemical
GDC-0623 ≥98%
10mg
$ 165.00

Cayman Chemical
GDC-0623 ≥98%
25mg
$ 248.00

Total 24 raw suppliers

Chemical Property of GDC-0623

Chemical Property:

PKA:14.17±0.10(Predicted)
PSA：87.89000
Density:1.81±0.1 g/cm3(Predicted)
LogP:2.93920
Solubility.:insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

GDC 0623 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.

Technology Process of GDC-0623

There total 1 articles about GDC-0623 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1168091-70-0
5-(2-fluoro-4-iodophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-vinyloxyethoxy)-amide

: 1168091-68-6
5-(2-fluoro-4-iodophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxyethoxy)-amide

Guidance literature:: 5-(2-fluoro-4-iodophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-vinyloxyethoxy)-amide; With hydrogenchloride; water; In methanol; at 20 ℃; for 0.75h;

With sodium hydrogencarbonate; In tert-butyl methyl ether; water; ethyl acetate; Product distribution / selectivity; sonication;