JNJ-40569321-AAA

Base Information

Chemical Name:JNJ-40569321-AAA
CAS No.:1092067-85-0
Molecular Formula:C₃₁H₃₅Cl₂N₅O₃
Molecular Weight:596.557
Hs Code.:
Mol file:1092067-85-0.mol

Synonyms:

Suppliers and Price of JNJ-40569321-AAA

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of JNJ-40569321-AAA

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of JNJ-40569321-AAA

There total 8 articles about JNJ-40569321-AAA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.7%

: 1092069-55-0
C₁₂H₁₂Cl₂N₂O

: 1092069-34-5
CH₄O₃S*C₁₉H₂₃N₃O₂

: 1092067-85-0
N-[2,6-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]4-(4-{[(4-methoxyphenyl)-acetyl]amino}phenyl)piperazine-1-carboxamide

Guidance literature:: C₁₂H₁₂Cl₂N₂O; CH₄O₃S*C₁₉H₂₃N₃O₂; With triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 2h; Molecular sieve;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 947673-12-3
benzyl 4-(4-aminophenyl)piperazine-1-carboxylate

: 1092067-85-0
N-[2,6-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]4-(4-{[(4-methoxyphenyl)-acetyl]amino}phenyl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 0.75 h / 60 °C

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 2 h / 20 °C / Molecular sieve

With thionyl chloride; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 947673-13-4
benzyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1092067-85-0
N-[2,6-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]4-(4-{[(4-methoxyphenyl)-acetyl]amino}phenyl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 5 % platinum on carbon / tetrahydrofuran; methanol / 50 °C

2.1: thionyl chloride / 0.75 h / 60 °C

2.2: 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 2 h / 20 °C / Molecular sieve

With thionyl chloride; hydrogen; triethylamine; 5 % platinum on carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;