Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

Technology Process of Auristatin E

Auristatin E

Base Information
  • Chemical Name:Auristatin E
  • CAS No.:160800-57-7
  • Molecular Formula:C40H69N5O7
  • Molecular Weight:732.01
  • Hs Code.:
  • European Community (EC) Number:814-537-0
  • ChEMBL ID:CHEMBL4082989
  • Nikkaji Number:J1.915.647H
  • Wikidata:Q76421607
  • Mol file:160800-57-7.mol
Auristatin E

Synonyms:Auristatin E;160800-57-7;Auristatin E (GMP);(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide;(S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide;SCHEMBL1687439;CHEMBL4082989;WOWDZACBATWTAU-FEFUEGSOSA-N;AMY10330;EX-A3360;HY-15582G;AKOS040741181;CS-3435;BP-23645;HY-15582;MS-31271;CS-0899140;F85071;L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

Suppliers and Price of Auristatin E
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • DC Chemicals
  • AuristatinE >98%
  • 1 g
  • $ 3500.00
  • DC Chemicals
  • AuristatinE >98%
  • 250 mg
  • $ 1800.00
  • DC Chemicals
  • AuristatinE >98%
  • 100 mg
  • $ 950.00
  • ChemScene
  • AuristatinE 99.36%
  • 10mg
  • $ 740.00
  • ChemScene
  • AuristatinE 99.36%
  • 5mg
  • $ 440.00
  • ChemScene
  • AuristatinE 99.36%
  • 1mg
  • $ 150.00
  • BroadPharm
  • AuristatinE 95%
  • 50 MG
  • $ 1300.00
Total 25 raw suppliers
Chemical Property of Auristatin E
Chemical Property:
  • Melting Point:92-94 °C 
  • Boiling Point:871.0±65.0 °C(Predicted) 
  • PKA:13.66±0.20(Predicted) 
  • PSA：140.75000 
  • Density:1.085±0.06 g/cm3(Predicted) 
  • LogP:4.59170 
  • XLogP3:4.5
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:20
  • Exact Mass:731.51969956
  • Heavy Atom Count:52
  • Complexity:1130
Purity/Quality:

99%, *data from raw suppliers

AuristatinE >98% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Canonical SMILES:CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C
  • Isomeric SMILES:CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C
  • Description Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778.
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 160800-57-7

Total 8 Pictures about this product