b-AP15

Base Information

• Chemical Name: b-AP15
• CAS No.: 330450-45-8
• Molecular Formula: C₂₂H₁₇N₃O₆
• Molecular Weight: 419.393
• Mol file: 330450-45-8.mol

Synonyms:b-AP15;NSC-687852;NSC687852 >=98% (HPLC);(3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one

Chemical Property of b-AP15

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

NSC 687852 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of b-AP15

There total 4 articles about b-AP15 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

acryloyl chloride (814-68-6,25189-84-8) + (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one (919091-63-7) → (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-(prop-2-enoyl)piperidin-4-one (330450-45-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 12h;

DOI:10.1021/jm0002580

Reference yield:

4-nitrobenzaldehdye (555-16-8) → (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-(prop-2-enoyl)piperidin-4-one (330450-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / AcOH; HCl(gas) / 24 h / 20 °C

2: 68 percent / aq. K₂CO₃ / acetone / 12 h / 20 °C

With hydrogenchloride; potassium carbonate; acetic acid; In acetone;

DOI:10.1021/jm0002580

Reference yield:

4-piperidone hydrochloride (41979-39-9) → (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-(prop-2-enoyl)piperidin-4-one (330450-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / AcOH; HCl(gas) / 24 h / 20 °C

2: 68 percent / aq. K₂CO₃ / acetone / 12 h / 20 °C

With hydrogenchloride; potassium carbonate; acetic acid; In acetone;

DOI:10.1021/jm0002580

upstream raw materials:

acryloyl chloride

(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one

4-piperidone hydrochloride

4-nitrobenzaldehdye