A-385358

Base Information

• Chemical Name: A-385358
• CAS No.: 406228-55-5
• Molecular Formula: C₃₂H₄₁N₅O₅S₂
• Molecular Weight: 639.84
• Mol file: 406228-55-5.mol

Synonyms:

Chemical Property of A-385358

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of A-385358

There total 27 articles about A-385358 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4,4-dimethylpiperidin-1-yl)benzoic acid (406233-26-9) + 4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide (406233-35-0) → (R)-4-(3-dimethylamino-1-phenylsulfanylmethylpropylamino)-N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitrobenzenesulfonamide (406228-55-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jm050754u

Reference yield:

4-(4,4-dimethylpiperidin-1-yl)benzoic acid (406233-26-9) + 4-((S)-3-dimethylamino-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide (872866-39-2) → 4-(3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-N-[4-(4,4-dimethyl-piperidin-1-yl)-benzoyl]-3-nitro-benzenesulfonamide (406228-55-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jm050754u

Reference yield:

4-fluoro-3-nitrobenzenesulfonamide (406233-31-6) → (R)-4-(3-dimethylamino-1-phenylsulfanylmethylpropylamino)-N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitrobenzenesulfonamide (406228-55-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 68 percent / DIPEA / dimethylformamide / 12 h / 20 °C

2: 99 percent / HCl / dioxane / 6 h / 20 °C

3: 56 percent / EDCI; DMAP / tetrahydrofuran; dimethylformamide / 16 h / 20 °C

4: 99 percent / BH₃ / tetrahydrofuran / 16 h / 20 °C

5: EDCI; DMAP / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; dmap; borane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050754u

upstream raw materials:

4-(4,4-dimethylpiperidin-1-yl)benzoic acid

4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide

4-fluoro-3-nitrobenzenesulfonamide

ethyl 4-(4,4-dimethylpiperidin-1-yl)benzoate