Technology Process of Benzo[3,4]-18-norandrosta-3,5-diene-3(2'H)-carboxylic acid, 3',4',5',6'-tetrahydro-4',4',9,14-tetraMethyl-17-oxo-, Methyl ester, (3β,4β,8α,9β,10α,13α,14β)- (9CI)
There total 7 articles about Benzo[3,4]-18-norandrosta-3,5-diene-3(2'H)-carboxylic acid, 3',4',5',6'-tetrahydro-4',4',9,14-tetraMethyl-17-oxo-, Methyl ester, (3β,4β,8α,9β,10α,13α,14β)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![(3aR,5aR,5bS,7aS,11aS,13aR,13bR)-5a,5b,10,10,13b-Pentamethyl-3-oxo-1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-cyclopenta[a]chrysene-7a-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
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211516-63-1
(3aR,5aR,5bS,7aS,11aS,13aR,13bR)-5a,5b,10,10,13b-Pentamethyl-3-oxo-1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-cyclopenta[a]chrysene-7a-carboxylic acid methyl ester
- Guidance literature:
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With
ruthenium tetroxide;
In
tetrachloromethane; water;
for 2h;
Ambient temperature;
DOI:10.1021/jo980525y
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211516-63-1
(3aR,5aR,5bS,7aS,11aS,13aR,13bR)-5a,5b,10,10,13b-Pentamethyl-3-oxo-1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-cyclopenta[a]chrysene-7a-carboxylic acid methyl ester
- Guidance literature:
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Multi-step reaction with 2 steps
1.1: 80 percent / phosphorus pentachloride / tetrachloroethene / 0.42 h / -15 °C
2.1: ozone; pyridine / CH2Cl2 / 0.33 h / -72 °C
2.2: 68 percent / dimethyl sulfide / CH2Cl2 / 3 h / cooling
With
pyridine; phosphorus pentachloride; ozone;
In
1,1,2,2-tetrachloroethylene; dichloromethane;
DOI:10.1021/jo026832s
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211516-63-1
(3aR,5aR,5bS,7aS,11aS,13aR,13bR)-5a,5b,10,10,13b-Pentamethyl-3-oxo-1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-cyclopenta[a]chrysene-7a-carboxylic acid methyl ester
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: 87 percent / triphenylphosphine; diethyl azodicarboxylate / dimethylformamide / 2 h / Heating
2.1: 43 percent / NaBH3CN; trifluoroacetic acid / tetrahydrofuran / 2.5 h / Heating
3.1: 80 percent / phosphorus pentachloride / tetrachloroethene / 0.42 h / -15 °C
4.1: ozone; pyridine / CH2Cl2 / 0.33 h / -72 °C
4.2: 68 percent / dimethyl sulfide / CH2Cl2 / 3 h / cooling
With
pyridine; phosphorus pentachloride; sodium cyanoborohydride; ozone; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
In
tetrahydrofuran; 1,1,2,2-tetrachloroethylene; dichloromethane; N,N-dimethyl-formamide;
1.1: Mitsunobu reaction;
DOI:10.1021/jo026832s
