LCI699

Base Information

Chemical Name:LCI699
CAS No.:928134-65-0
Molecular Formula:C13H10FN3
Molecular Weight:227.241
Hs Code.:
Mol file:928134-65-0.mol

Synonyms:(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile;4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile;3-quinoline;4-((R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile;4-(quinolin-3-ylmethyl-amino)-benzenesulfonamide;Novartis LCI699;

Suppliers and Price of LCI699

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Isturisa(Osilodrostat) >98%
250 mg
$ 1450.00

Crysdot
LCI699 95+%
25mg
$ 655.00

Crysdot
LCI699 95+%
10mg
$ 352.00

Crysdot
LCI699 95+%
100mg
$ 1521.00

Crysdot
LCI699 95+%
50mg
$ 941.00

ChemScene
Osilodrostat 99.17%
100mg
$ 850.00

ChemScene
Osilodrostat 99.17%
10mg
$ 150.00

ChemScene
Osilodrostat 99.17%
5mg
$ 100.00

Total 40 raw suppliers

Chemical Property of LCI699

Chemical Property:

Boiling Point:433.8±45.0 °C(Predicted)
PKA:6.97±0.40(Predicted)
PSA：41.61000
Density:1.32±0.1 g/cm3(Predicted)
LogP:2.42948

Purity/Quality:

99%, ^*data from raw suppliers

Isturisa(Osilodrostat) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Osilodrostat is a novel 11-β-hydroxylase inhibitor which may be used in the treatment of Cushing’s syndrome,

Technology Process of LCI699

There total 16 articles about LCI699 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

: 4-[(5R)-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile

: 928134-65-0
(+)-(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 30 - 35 ℃; for 4h; under 1500.15 - 3000.3 Torr;

Reference yield:

: racemic-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

: 928134-65-0
(+)-(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

: 928134-66-1
(S)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

Guidance literature:: Purification / work up; Resolution of racemate;

Reference yield:

: 105942-09-4
4-(bromomethyl)-3-fluorobenzonitrile

: 928134-65-0
(+)-(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

: 928134-66-1
(S)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane; acetonitrile / 30 h / 20 °C

1.2: 1 h / 80 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2 h / -78 °C

3.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 °C

5.1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C

6.1: lithium hydroxide / tetrahydrofuran; ethanol / 1.5 h / 20 °C

7.1: ethanol / 3 h / 80 °C / Sealed tube

8.1: Resolution of racemate

With hydrogenchloride; potassium carbonate; triethylamine; sodium iodide; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ml400324c