INCB3344

Base Information

Chemical Name:INCB3344
CAS No.:1262238-11-8
Molecular Formula:C₂₉H₃₄F₃N₃O₆
Molecular Weight:577.601
Hs Code.:
Mol file:1262238-11-8.mol

Synonyms:INCB 3344;INCB-3344;rel-N-[2-[[(3R,4R)-1-[trans-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-

Suppliers and Price of INCB3344

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
INCB3344 >98%
1 g
$ 2800.00

DC Chemicals
INCB3344 >98%
100 mg
$ 700.00

Crysdot
INCB3344 98+%
50mg
$ 590.00

Crysdot
INCB3344 98+%
10mg
$ 219.00

Crysdot
INCB3344 98+%
5mg
$ 167.00

Crysdot
INCB3344 98+%
100mg
$ 913.00

ChemScene
INCB3344 99.73%
100mg
$ 1200.00

ChemScene
INCB3344 99.73%
50mg
$ 810.00

ChemScene
INCB3344 99.73%
5mg
$ 190.00

ChemScene
INCB3344 99.73%
10mg
$ 290.00

Total 20 raw suppliers

Chemical Property of INCB3344

Chemical Property:

Boiling Point:736.3±60.0 °C(Predicted)
PKA:12.94±0.46(Predicted)
PSA：0.00000
Density:1.38±0.1 g/cm3(Predicted)
LogP:4.41500
Solubility.:≥25.9 mg/mL in DMSO; insoluble in H2O; ≥89.8 mg/mL in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

INCB3344 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description INCB 3344 is an antagonist of chemokine (C-C motif) receptor 2 (CCR2; IC50 = 10 nM in WEHI-274 murine monocytes). It is selective for CCR2 over a panel of G protein-coupled receptors, including CCR1 and CCR5, with IC50s values greater than 1 μM. INCB 3344 inhibits chemotaxis of WEHI-274 cells induced by chemokine (C-C motif) ligand 2 (CCL2; IC50 = 10 nM) and CCL2-induced phosphorylation of ERK in WEHI-274 cells. It inhibits monocyte influx in a mouse model of peritonitis induced by thioglycolate when administered at doses of 60 and 100 mg/kg. INCB 3344 (30, 50, and 100 mg/kg twice per day) decreases the expression of CCR2 mRNA in the ear and reduces ear swelling in a mouse model of delayed-type hypersensitivity reaction. It prevents increases in or reduces macrophage levels in the spinal cord when administered at a dose of 100 mg/kg per day beginning the day of immunization or seven days following immunization, respectively, in a mouse model of experimental autoimmune encephalomyelitis (EAE). It also reduces disease incidence and severity in the same model and reduces disease severity in a rat model of adjuvant-induced arthritis. INCB 3344 reduces macrophage infiltration to the kidney and improves renal function in a mouse model of polycystic kidney disease.

Technology Process of INCB3344

There total 2 articles about INCB3344 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: