Chemical Property of LEE011
Chemical Property:
- Boiling Point:679.3±65.0 °C(Predicted)
- PKA:7.57±0.50(Predicted)
- PSA：85.86000
- Density:1.31±0.1 g/cm3(Predicted)
- LogP:4.45050
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Purity/Quality:
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99%, *data from raw suppliers
CDK4/6Inhibitor *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
LEE011 (also known as ribociclib) is a CDK4/6 inhibitor. It has been recently approved by FDA (brand name: Kisqali?) to be combined with an aromatase inhibitor for initial endocrine-based therapy for treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis.
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Uses
CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer.
