Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Base Information

Chemical Name:Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
CAS No.:325970-71-6
Molecular Formula:C16H14Br2N4O4
Molecular Weight:486.11
Hs Code.:
Mol file:325970-71-6.mol

Synonyms:L67 >=98% (HPLC);DNA LIGASE INHIBITOR; L-67; L 67;Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Suppliers and Price of Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
L67 >98%
100 mg
$ 420.00

DC Chemicals
L67 >98%
250 mg
$ 800.00

DC Chemicals
L67 >98%
1 g
$ 1700.00

Crysdot
L67 98+%
100mg
$ 1470.00

Crysdot
L67 98+%
50mg
$ 1050.00

Crysdot
L67 98+%
5mg
$ 245.00

Crysdot
L67 98+%
10mg
$ 350.00

ChemScene
L67 >98.0%
100mg
$ 280.00

ChemScene
L67 >98.0%
50mg
$ 180.00

ChemScene
L67 >98.0%
10mg
$ 80.00

Total 11 raw suppliers

Chemical Property of Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Chemical Property:

PSA：119.54000
LogP:4.68310

Purity/Quality:

99%, ^*data from raw suppliers

L67 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM.
Uses L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design.

Technology Process of Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

There total 2 articles about Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 882760-09-0
N-(3,5-dibromo-4-methylphenyl)glycine hydrazide

: 97-51-8
5-Nitrosalicylaldehyde

: 325970-71-6
C₁₆H₁₄Br₂N₄O₄

Guidance literature:: In ethanol;

Reference yield:

: 13194-73-5
3,5-dibromo-4-methylaniline

: 325970-71-6
C₁₆H₁₄Br₂N₄O₄

Guidance literature:: Multi-step reaction with 3 steps

1: lithium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 100 °C

2: hydrazine hydrate / propan-1-ol / 64 h / Reflux

3: ethanol

With lithium carbonate; hydrazine hydrate; In 1-methyl-pyrrolidin-2-one; propan-1-ol; ethanol;