EMD638683

Base Information

Chemical Name:EMD638683
CAS No.:1181770-72-8
Molecular Formula:C18H18F2N2O4
Molecular Weight:364.349
Hs Code.:
Mol file:1181770-72-8.mol

Synonyms:]-2-ethyL;EMD638683;N'-[2-(3,5-DifL;)-2-hydroxyacetyL;-4-hydroxy-3-methyL;EMD 638683;EMD-638683;N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide;2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide;Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide;3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide

Suppliers and Price of EMD638683

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
EMD638683 >98%
250 mg
$ 1500.00

DC Chemicals
EMD638683 >98%
1 g
$ 3000.00

Crysdot
EMD638683 98+%
100mg
$ 1064.00

Crysdot
EMD638683 98+%
50mg
$ 589.00

Crysdot
EMD638683 98+%
10mg
$ 218.00

Crysdot
EMD638683 98+%
5mg
$ 169.00

ChemScene
EMD638683 99.74%
100mg
$ 1800.00

ChemScene
EMD638683 99.74%
50mg
$ 1086.00

ChemScene
EMD638683 99.74%
5mg
$ 312.00

ChemScene
EMD638683 99.74%
10mg
$ 402.00

Total 17 raw suppliers

Chemical Property of EMD638683

Chemical Property:

Boiling Point:657.6±55.0 °C(Predicted)
PKA:8.68±0.25(Predicted)
PSA：102.15000
Density:1.363±0.06 g/cm3(Predicted)
LogP:3.26700
Solubility.:insoluble in H2O; ≥18.2 mg/mL in DMSO; ≥45.8 mg/mL in EtOH with gentle warming

Purity/Quality:

99%, ^*data from raw suppliers

EMD638683 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of EMD638683

There total 7 articles about EMD638683 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1181770-80-8
N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-methoxy-3-methylbenzohydrazide

: 1181770-72-8
EMD 638683

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 132741-31-2
S-(+)-3.5-Difluoromandelic Acid

: 1181770-72-8
EMD 638683

Guidance literature:: Multi-step reaction with 4 steps

1: boric acid / methanol / 18 h / 20 °C

2: hydrazine hydrate / isopropyl alcohol / 18 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

4: boron tribromide / dichloromethane / 3 h / 20 °C

With boric acid; boron tribromide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 208259-37-4,209982-92-3
methyl 2-(3,5-difluorophenyl)-2-hydroxyacetate

: 1181770-72-8
EMD 638683

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / isopropyl alcohol / 18 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

3: boron tribromide / dichloromethane / 3 h / 20 °C

With boron tribromide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;