PRT062607 acetate

Base Information

Chemical Name:PRT062607 acetate
CAS No.:1370261-98-5
Molecular Formula:C₂H₄O₂*C₁₉H₂₃N₉O
Molecular Weight:453.504
Hs Code.:
Mol file:1370261-98-5.mol

Synonyms:5-Pyrimidinecarboxamide,2-(((1R,2S)-2-aminocyclohexyl)amino)-4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-,acetate (1:1);PRT-062607 acetate;

Suppliers and Price of PRT062607 acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-((3-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamideacetate 97%
250mg
$ 1206.00

Crysdot
4-((3-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamideacetate 97%
50mg
$ 401.00

Total 2 raw suppliers

Chemical Property of PRT062607 acetate

Chemical Property:

PSA：186.96000
LogP:3.21910

Purity/Quality:: 4-((3-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamideacetate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of PRT062607 acetate

There total 18 articles about PRT062607 acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5
(1S,2S)-trans-2-aminocyclohexanol

: 1370261-98-5
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R, 2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide acetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 0 - 20 °C / Large scale

2.1: triethylamine / dichloromethane / 0.17 h / 5 °C / Large scale

2.2: 2 h / 20 °C / Large scale

3.1: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 6 h / 100 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 750.08 Torr

5.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 4 h / 5 - 40 °C

5.2: 2 h / 60 - 70 °C

6.1: hydrogenchloride / ethyl acetate / 4 h / 0 - 30 °C / Large scale

6.2: 0.5 h / 45 - 50 °C / Large scale

With hydrogenchloride; sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1436-59-5
cis-cyclohexane-1,2-diamine

: 1370261-98-5
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R, 2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide acetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol / 2 h / 0 - 5 °C / Inert atmosphere; Large scale

1.2: 20 °C / Inert atmosphere; Large scale

2.1: (R)-Mandelic Acid / ethyl acetate / Large scale

2.2: 3 h / 20 - 30 °C / Large scale

3.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 4 h / 5 - 40 °C

3.2: 2 h / 60 - 70 °C

4.1: hydrogenchloride / ethyl acetate / 4 h / 0 - 30 °C / Large scale

4.2: 0.5 h / 45 - 50 °C / Large scale

With hydrogenchloride; (R)-Mandelic Acid; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; ethanol; ethyl acetate;

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 1370261-98-5
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R, 2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide acetic acid salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: water / 5 h / Reflux; Large scale

2.1: (R)-Mandelic Acid / ethanol; ethyl acetate / 16 h / 15 - 65 °C

2.2: 0.33 h

3.1: palladium(II) hydroxide; hydrogen / methanol / 20 °C / 2068.65 Torr

4.1: triethylamine / 0 - 20 °C / Large scale

5.1: triethylamine / dichloromethane / 0.17 h / 5 °C / Large scale

5.2: 2 h / 20 °C / Large scale

6.1: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 6 h / 100 °C

7.1: hydrogen; palladium 10% on activated carbon / methanol / 750.08 Torr

8.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 4 h / 5 - 40 °C

8.2: 2 h / 60 - 70 °C

9.1: hydrogenchloride / ethyl acetate / 4 h / 0 - 30 °C / Large scale

9.2: 0.5 h / 45 - 50 °C / Large scale

With hydrogenchloride; sodium azide; 15-crown-5; palladium 10% on activated carbon; (R)-Mandelic Acid; hydrogen; palladium(II) hydroxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;