Tideglusib

Base Information

Chemical Name:Tideglusib
CAS No.:865854-05-3
Molecular Formula:C₁₉H₁₄N₂O₂S
Molecular Weight:334.398
Hs Code.:
UNII:Q747Y6TT42
ChEMBL ID:CHEMBL3545157
DSSTox Substance ID:DTXSID90235682
Metabolomics Workbench ID:153175
NCI Thesaurus Code:C97364
Nikkaji Number:J3.394.601E
Pharos Ligand ID:6KT4AM8RC22H
Wikidata:Q10382411
Wikipedia:Tideglusib
Mol file:865854-05-3.mol

Synonyms:4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione;NP 031112;NP-031112;NP-12 compound;NP031112;NP12 compound;tideglusib

Suppliers and Price of Tideglusib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tideglusib
25mg
$ 120.00

Sigma-Aldrich
Tideglusib ≥98% (HPLC)
10mg
$ 106.00

Sigma-Aldrich
Tideglusib ≥98% (HPLC)
50mg
$ 423.00

Medical Isotopes, Inc.
Tideglusib
200 mg
$ 925.00

DC Chemicals
Tideglusib(NP-031112) >98%
250 mg
$ 400.00

DC Chemicals
Tideglusib(NP-031112) >98%
100 mg
$ 200.00

Crysdot
Tideglusib(NP-031112) 98+%
100mg
$ 259.00

ChemScene
Tideglusib 99.66%
100mg
$ 319.00

ChemScene
Tideglusib 99.66%
10mg
$ 100.00

ChemScene
Tideglusib 99.66%
50mg
$ 168.00

Total 83 raw suppliers

Chemical Property of Tideglusib

Chemical Property:

Boiling Point:511.3±43.0 °C(Predicted)
PKA:-1.51±0.20(Predicted)
PSA：72.24000
Density:1.393
LogP:3.26220
Storage Temp.:2-8°C
Solubility.:DMSO: >15mg/mL
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:334.07759887
Heavy Atom Count:24
Complexity:492

Purity/Quality:

99%, ^*data from raw suppliers

Tideglusib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43
Recent ClinicalTrials:Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
Recent EU Clinical Trials:A Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Tideglusib Versus Placebo for the Treatment of Children and Adolescents with Congenital Myotonic Dystrophy
Uses Tideglusib is used in the treatment of brain atrophy, and movement disorder issues. Tideglusib has been used:as a reference compound in ADP-GloTM Kinase assayas an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells

Technology Process of Tideglusib

There total 3 articles about Tideglusib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 865854-05-3
Tideglusib

Guidance literature:

Reference yield:

: C₁₉H₁₄Cl₂N₂OS

: 865854-05-3
Tideglusib

Guidance literature:: With air; In tetrahydrofuran; for 0.5h;
DOI:10.1021/acs.jmedchem.0c00803

Reference yield:

: 622-78-6
Benzyl isothiocyanate

: 86-84-0
1-Naphthyl isocyanate

: 865854-05-3
Tideglusib

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 0 - 20 °C

2: air / tetrahydrofuran / 0.5 h

With thionyl chloride; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.0c00803