Chemical Property of Edoxaban (tosylate monohydrate)
Chemical Property:
- PSA：236.85000
- LogP:4.34050
- Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
- Solubility.:Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
- Purity/Quality:
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99%min *data from raw suppliers
Edoxaban Tosylate Monohydrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Uses
Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.
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Clinical Use
Daichi Sankyo’s edoxaban tosilate is an orally administered
coagulation factor Xa inhibitor that was approved and launched
in Japan for the preventive treatment of venous thromboembolic
events (VTE) in patients undergoing total knee arthroplasty, total
hip arthroplasty, or hip fracture surgery. Edoxaban has been
shown to have a rapid onset of anticoagulant effect due to short
Tmax (1–2 h) after dosing and sustained for up to 24 h post-dose.
Marketed under the brand name Lixiana, it is currently in phase
III studies in the US for the prevention of stroke and systemic embolic
events in patients with atrial fibrillation (AF) and venous
thromboembolism (VTE).
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Drug interactions
Potentially hazardous interactions with other drugsAnalgesics: increased risk of bleeding with NSAIDs
and high dose aspirin; increased risk of haemorrhage
with IV diclofenac and ketorolac - avoidAnti-arrhythmics: concentration increased by
dronedarone (reduce edoxaban dose)Antibacterials: concentration increased by
erythromycin (reduce edoxaban dose); concentration
reduced by rifampicin.Anticoagulants: increased risk of haemorrhage with
other anticoagulants - avoid.Antidepressants: concentration possibly reduced by
St John’s wort.Antiepileptics: concentration possibly reduced
by carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.Antifungals: concentration increased by ketoconazole
(reduce edoxaban dose).Ciclosporin: concentration of edoxaban increased
(reduce edoxaban dose).
