EVP-6124 (hydrochloride)

Base Information

• Chemical Name: EVP-6124 (hydrochloride)
• CAS No.: 550999-74-1
• Molecular Formula: C16H17ClN2OS.ClH
• Molecular Weight: 357.29792
• Mol file: 550999-74-1.mol

Synonyms:EVP-6124 (hydrochloride);Encenicline, HCl salt;(R)-7-Chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride

Chemical Property of EVP-6124 (hydrochloride)

Chemical Property:

• PSA: 60.58000
• LogP: 4.50950
• Solubility.: insoluble in H2O; ≥100.4 mg/mL in EtOH with gentle warming; ≥17.87 mg/mL in DMSO

Purity/Quality:

97% ^*data from raw suppliers

EnceniclineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Encenicline hydrochloride is a selective partial agonist of the a7 nicotinic acetylcholine receptor being developed for the cognitive impairment in Alzheimer’s disease and schizophrenia.

Technology Process of EVP-6124 (hydrochloride)

There total 8 articles about EVP-6124 (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

EVP-6124 (550999-75-2) → (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride (550999-74-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.166667h;

Reference yield: 78.0%

7-chlorobenzo[b]thiophene-2-carboxylic acid chloride (244126-68-9) + (3R)-quinuclidin-3-amine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride (550999-74-1)

Guidance literature:

With 1H-imidazole; In acetonitrile; at 15 - 30 ℃; for 24h;

Reference yield: 78.0%

7-chlorobenzo[b]thiophene-2-carboxylic acid chloride (244126-68-9) + (3R)-quinuclidin-3-amine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride (550999-74-1)

Guidance literature:

7-chlorobenzo[b]thiophene-2-carboxylic acid chloride; With 1H-imidazole; In acetonitrile;

(3R)-quinuclidin-3-amine dihydrochloride; With 1H-imidazole; In acetonitrile; at 20 - 24 ℃;

DOI:10.3987/COM-18-S(F)97

upstream raw materials:

7-chlorobenzo[b]thiophene-2-carboxylic acid

EVP-6124

7-chlorobenzo[b]thiophene-2-carboxylic acid chloride

(3R)-quinuclidin-3-amine dihydrochloride