Chemical Property of Lonsurf
Chemical Property:
- PSA：104.81000
- LogP:-0.39160
- Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
- Solubility.:DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
- Hydrogen Bond Donor Count:7
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:4
- Exact Mass:574.0957370
- Heavy Atom Count:37
- Complexity:869
- Purity/Quality:
-
99%, *data from raw suppliers
TAS102(2:1) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O.Cl
- Isomeric SMILES:C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O.Cl
- Recent ClinicalTrials:Study of Lonsurf in Combination With Gemcitabine and Nab-Paclitaxel in Patients With Advanced (PDAC)
- Recent EU Clinical Trials:EXPLOITING CIRCULATING TUMOUR DNA TO INTENSIFY THE POST-OPERATIVE TREATMENT OF STAGE III AND HIGH-RISK STAGE II RESECTED COLON CANCER PATIENTS WITH ADJUVANT FOLFOXIRI AND/OR POST-ADJUVANT TRIFLURIDINE/TIPIRACIL.
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Uses
TAS 102 (Tipiracil-trifluridine) is a thymidine phosphorylase inhibitor used in chemotherapy treatment of advanced/recurring colorectal cancer.
