Chemical Property of Teneligliptin
Chemical Property:
- PSA：163.88000
- LogP:8.46190
- Storage Temp.:Refrigerator
- Solubility.:Methanol (Slightly)
- Hydrogen Bond Donor Count:7
- Hydrogen Bond Acceptor Count:12
- Rotatable Bond Count:8
- Exact Mass:1256.06708
- Heavy Atom Count:65
- Complexity:594
- Purity/Quality:
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99% *data from raw suppliers
TeneligliptinHydrobromide(2:5) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.Br.Br.Br.Br.Br
- Isomeric SMILES:CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5.Br.Br.Br.Br.Br
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Uses
Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
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Clinical Use
Teneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II
diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name
Tenelia?. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and
QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1
levels, with very low rates of renal excretion.
