Urea, N-(1-((2-amino-4-pyridinyl)methyl)-1H-indol-4-yl)-N'-(5-bromo-2-methoxyphenyl)-

Base Information

Chemical Name:Urea, N-(1-((2-amino-4-pyridinyl)methyl)-1H-indol-4-yl)-N'-(5-bromo-2-methoxyphenyl)-
CAS No.:900573-88-8
Molecular Formula:C₂₂H₂₀BrN₅O₂
Molecular Weight:466.337
Hs Code.:
UNII:980M4N37DH
ChEMBL ID:CHEMBL3545155
Metabolomics Workbench ID:153676
NCI Thesaurus Code:C82413
Nikkaji Number:J3.513.049G
Wikidata:Q27272064
Mol file:900573-88-8.mol

Synonyms:1-(1-(2-amino-pyridin-4-ylmethyl)-1H-indol-4-yl)-3-(5-bromo-2-methoxyphenyl)urea;JI 101;JI-101;JI101 cpd

Suppliers and Price of Urea, N-(1-((2-amino-4-pyridinyl)methyl)-1H-indol-4-yl)-N'-(5-bromo-2-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
JI-?101
10mg
$ 180.00

DC Chemicals
JI-101 >98%
1 g
$ 2200.00

DC Chemicals
JI-101 >98%
100 mg
$ 650.00

DC Chemicals
JI-101 >98%
250 mg
$ 1100.00

Crysdot
JI-101 98+%
50mg
$ 750.00

Crysdot
JI-101 98+%
10mg
$ 216.00

Crysdot
JI-101 98+%
100mg
$ 1250.00

ChemScene
JI-101 99.95%
100mg
$ 1320.00

ChemScene
JI-101 99.95%
50mg
$ 792.00

ChemScene
JI-101 99.95%
10mg
$ 228.00

Total 18 raw suppliers

Chemical Property of Urea, N-(1-((2-amino-4-pyridinyl)methyl)-1H-indol-4-yl)-N'-(5-bromo-2-methoxyphenyl)-

Chemical Property:

Boiling Point:606.9±55.0 °C(Predicted)
PKA:13.25±0.70(Predicted)
PSA：98.42000
Density:1.50±0.1 g/cm3(Predicted)
LogP:5.09860
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
XLogP3:3.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:465.08004
Heavy Atom Count:30
Complexity:582

Purity/Quality:

99%, ^*data from raw suppliers

JI-?101 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)Br)NC(=O)NC2=C3C=CN(C3=CC=C2)CC4=CC(=NC=C4)N
Recent ClinicalTrials:Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or K-RAS Mutant Colon Cancers
Uses JI-?101 is VEGFR2 inhibitor. It can be used as analyte in pharmacological activity and analytical study of assay methodologies and perspectives for quantitation of VEGFR2 inhibitors such as sunitinib, sorafenib, pazopanib and JI-101 which were involved in treatment of cancer in human and animal models including mouse.

Technology Process of Urea, N-(1-((2-amino-4-pyridinyl)methyl)-1H-indol-4-yl)-N'-(5-bromo-2-methoxyphenyl)-

There total 1 articles about Urea, N-(1-((2-amino-4-pyridinyl)methyl)-1H-indol-4-yl)-N'-(5-bromo-2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: