RO-5006036

Base Information

Chemical Name:RO-5006036
CAS No.:939375-07-2
Molecular Formula:C₂₀H₁₉F₃N₄O₃
Molecular Weight:420.391
Hs Code.:

Synonyms:DGAT1-IN-3;RO-5006036;4-Oxazolecarboxamide, N-[6-[(2-methoxyethyl)methylamino]-3-pyridinyl]-2-phenyl-5-(trifluoromethyl)-;N-[6-[2-methoxyethyl(methyl)amino]pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide

Suppliers and Price of RO-5006036

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
DGAT1-IN-3
002
$ 1350.00

DC Chemicals
DGAT1-IN-3
001
$ 800.00

DC Chemicals
DGAT1-IN-3
003
$ 2700.00

ChemScene
DGAT1-IN-3 99.86%
100mg
$ 3000.00

ChemScene
DGAT1-IN-3 99.86%
50mg
$ 1900.00

ChemScene
DGAT1-IN-3 99.86%
10mg
$ 700.00

ChemScene
DGAT1-IN-3 99.86%
5mg
$ 420.00

Total 4 raw suppliers

Chemical Property of RO-5006036

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

DGAT1-IN-3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of RO-5006036

There total 4 articles about RO-5006036 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 236736-23-5
2-phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid

: 939376-46-2
2-N-(2-methoxyethyl)-2-N-methylpyridine-2,5-diamine

: 939375-07-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}amide

Guidance literature:: With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/jm101580m

Reference yield:

: 1279083-88-3
N-(2-methoxyethyl)-N-methyl-5-nitropyridin-2-amine

: 939375-07-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}amide

Guidance literature:: Multi-step reaction with 2 steps

1: 5% Pd(II)/C(eggshell); hydrogen / tetrahydrofuran; methanol / 1 h

2: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm101580m

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 939375-07-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: 5% Pd(II)/C(eggshell); hydrogen / tetrahydrofuran; methanol / 1 h

3: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm101580m