1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-

Base Information

Chemical Name:1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-
CAS No.:1233145-49-7
Molecular Formula:C₂₇H₃₀N₆O₃
Molecular Weight:486.574
Hs Code.:
Mol file:1233145-49-7.mol

Synonyms:1-PiperidineacetaMide, 4-[3-Methoxy-4-[[7-(2-Methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]aMino]phenyl]-;2-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide

Suppliers and Price of 1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-

Chemical Property:

PSA：107.01000
LogP:4.53300

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-

There total 7 articles about 1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232784-37-0
C₁₃H₁₁N₃O₂

: 1233145-49-7
2-(4-{3-methoxy-4-[7-(2-methoxyphenyl)pyrrolo-[2,1-f ][1,2,4]triazin-2-ylamino]phenyl}piperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 20 °C

2.1: N,N-dimethyl-formamide / Heating

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm2010767

Reference yield:

: 1233145-65-7
4-(3-methoxy-4-nitro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1233145-49-7
2-(4-{3-methoxy-4-[7-(2-methoxyphenyl)pyrrolo-[2,1-f ][1,2,4]triazin-2-ylamino]phenyl}piperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: caesium carbonate / acetonitrile / 75 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 2585.81 Torr

4: N,N-dimethyl-formamide / Heating

With palladium 10% on activated carbon; hydrogen; caesium carbonate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2010767

Reference yield:

: 1116228-85-3
4-(3-methoxy-4-nitro-phenyl)-1,2,3,6-tetrahydropyridine

: 1233145-49-7
2-(4-{3-methoxy-4-[7-(2-methoxyphenyl)pyrrolo-[2,1-f ][1,2,4]triazin-2-ylamino]phenyl}piperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 75 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 2585.81 Torr

3: N,N-dimethyl-formamide / Heating

With palladium 10% on activated carbon; hydrogen; caesium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2010767