cis-3-Aminocyclohexanol hydrochloride

Base Information

Chemical Name:cis-3-Aminocyclohexanol hydrochloride
CAS No.:124555-44-8
Molecular Formula:C₆H₁₃NO*ClH
Molecular Weight:151.636
Hs Code.:
European Community (EC) Number:873-302-0
DSSTox Substance ID:DTXSID90480731
Mol file:124555-44-8.mol

Synonyms:cis-3-aminocyclohexanol hydrochloride;124555-44-8;1849594-88-2;(1R,3S)-3-aminocyclohexan-1-ol hydrochloride;(1R,3S)-3-Amino-cyclohexanol hydrochloride;(1R,3S)-3-Aminocyclohexanol hydrochloride;cis-3-Amino-cyclohexanol hydrochloride;(1R,3S)-3-aminocyclohexan-1-ol;hydrochloride;C6H14ClNO;cis-3-aminocyclohexanol HCl;MFCD22689399;MFCD11870212;SCHEMBL2145087;DTXSID90480731;NJGXTVICXVECGR-RIHPBJNCSA-N;(1R,3S)-3-Aminocyclohexanol HCl;AMY37601;AS-0799;AT10758;(1R,3S)-3-Aminocyclohexan-1-Ol HCl;(1R,3S)-3-Aminocyclohexanolhydrochloride;AS-83981;CS-0042346;EN300-212435;Cis-(1R,3S)-3-amino-cyclohexanol hydrochloride;rel-(1R,3S)-3-aminocyclohexan-1-ol hydrochloride;Cyclohexanol, 3-amino-, hydrochloride, cis- (9CI)

Suppliers and Price of cis-3-Aminocyclohexanol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,3R)-3-AminocyclohexanolHydrochloride
250mg
$ 475.00

Crysdot
cis-3-Aminocyclohexanolhydrochloride 95+%
1g
$ 713.00

Chemenu
(1R,3S)-3-aminocyclohexan-1-olhydrochloride 95%
1g
$ 673.00

ChemBridge Corporation
cis-3-aminocyclohexanolhydrochloride 95%
250 mg
$ 170.00

American Custom Chemicals Corporation
RAC-(1R,3S)-3-AMINOCYCLOHEXANOL HYDROCHLORIDE 95.00%
5MG
$ 451.00

Total 14 raw suppliers

Chemical Property of cis-3-Aminocyclohexanol hydrochloride

Chemical Property:

PSA：46.25000
LogP:1.75090
Storage Temp.:Refrigerator, Under Inert Atmosphere
Solubility.:Methanol (Slightly), Water (Slightly)
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:151.0763918
Heavy Atom Count:9
Complexity:74.9

Purity/Quality:

99%, ^*data from raw suppliers

(1S,3R)-3-AminocyclohexanolHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CC(C1)O)N.Cl
Isomeric SMILES:C1C[C@@H](C[C@@H](C1)O)N.Cl
Uses (1S,3R)-3-Aminocyclohexanol Hydrochloride is used as a reactant in the preparation of isoxazole carboxamide compounds as potent, soluble, orally active TRPV1 antagonists and analgesics.

Technology Process of cis-3-Aminocyclohexanol hydrochloride

There total 9 articles about cis-3-Aminocyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1425253-99-1,1638744-95-2
C₁₁H₂₁NO₃

: 124555-43-7,124555-44-8,1849594-88-2
(+/-)-cis-3-amino-cyclohexanol; hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 1h;

Reference yield:

: 885280-38-6,1803033-61-5,1383797-87-2
(3-oxo-cyclohexyl)-carbamic acid tert-butyl ester

: 124555-43-7,124555-44-8,1849594-88-2
(+/-)-cis-3-amino-cyclohexanol; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: L-Selectride / tetrahydrofuran / 2 h / -78 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 0 - 25 °C

3: potassium carbonate / methanol / 16 h / 20 °C

4: hydrogenchloride / methanol / 1 h / 20 °C

With hydrogenchloride; L-Selectride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

Reference yield:

: 1541-26-0
2-cyclohex-2-enyl-isoindole-1,3-dione

: 124555-43-7,124555-44-8,1849594-88-2
(+/-)-cis-3-amino-cyclohexanol; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NBS / CHCl₃; ethanol / 8 h / Ambient temperature

2: 98 percent / 2 M HCl / methanol / 0.5 h / Ambient temperature

3: 80 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating

4: 1.) hydrazine hydrate, 2.) conc. HCl / 1.) 95 percent ethanol, reflux, 2 h, 2.) room temperature

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; hydrazine hydrate; In methanol; ethanol; chloroform; toluene;