Cis-3-AMINOCYCLOPENTANOL HCl salt

Base Information

• Chemical Name: Cis-3-AMINOCYCLOPENTANOL HCl salt
• CAS No.: 1284248-73-2
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.609
• Hs Code.: 2922190090
• Mol file: 1284248-73-2.mol

Synonyms:Cis-3-AMINOCYCLOPENTANOL HCl salt;cis-3-AMinocyclopentanol hydrochloride;Cis-3-AMINOCYCLOPENTANOL HCl;(1R,3S)-rel-3-AMinocyclopentanol hydrochloride;cis-3-Aminocyclopentan-1-ol hydrochloride;cis-3-Hydroxycyclopentan-1-amine hydrochloride, cis-1-Amino-3-hydroxycyclopentane hydrochloride

Chemical Property of Cis-3-AMINOCYCLOPENTANOL HCl salt

Chemical Property:

• PSA: 46.25000
• LogP: 1.36080
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

cis-3-Aminocyclopentan-1-ol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cis-3-AMINOCYCLOPENTANOL HCl salt

There total 33 articles about Cis-3-AMINOCYCLOPENTANOL HCl salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1S,3R)-3-hydroxycyclopentyl-1-carbamic acid tert-butyl ester (167465-99-8,1154870-59-3,207729-04-2) → (1R,3S)-3-amino-1-cyclopentanol hydrochloride (1279032-31-3,124555-33-5,1259436-59-3,1523541-74-3,1284248-73-2,1523530-42-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 82.0%

C13H17NO3 (1445796-28-0) → rac-3-aminocyclopentanol hydrochloride (1184919-69-4,124555-33-5,1259436-59-3,1523541-74-3,1284248-73-2,1523530-42-8)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Reflux;

Reference yield: 68.9%

(R)-2-hydroxy-N-((1S,3R)-3-hydroxycyclopentyl)propanamide → (1R,3S)-3-amino-1-cyclopentanol hydrochloride (1279032-31-3,124555-33-5,1259436-59-3,1523541-74-3,1284248-73-2,1523530-42-8)

Guidance literature:

With hydrogenchloride; In methanol; at 25 ℃;

upstream raw materials:

(1S,3R)-3-aminocyclopentane-1-ol

tert-butyl N-[(1R,3S)-3-hydroxycyclopentyl]carbamate

(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclopentylamine

(1S,3R)-3-hydroxycyclopentyl-1-carbamic acid tert-butyl ester

Downstream raw materials:

(2S,5R,13aS)-N-((R)-1-(4-fluorophenyl)ethyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

(2R,5S,13aR)-N-((R)-1-(4-fluorophenyl)ethyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Refernces

• 1、 -. "Preparation method of (1R,3S)-3-amino-1-cyclopentanol and salt thereof". Paragraph 0170; 0171; 0172; 0173; 0174. . Retrieved 2020/03/16.
• 2、 -. "SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS". Paragraph 0343; 0391. . Retrieved 2020/11/12.