Methyl 3-hydroxycyclopentanecarboxylate

Base Information

• Chemical Name: Methyl 3-hydroxycyclopentanecarboxylate
• CAS No.: 32811-76-0
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• European Community (EC) Number: 856-589-7
• DSSTox Substance ID: DTXSID601215959
• Mol file: 32811-76-0.mol

Synonyms:Methyl 3-hydroxycyclopentanecarboxylate;32811-76-0;methyl 3-hydroxycyclopentane-1-carboxylate;3-Hydroxy-cyclopentanecarboxylic acid methyl ester;methyl cis-3-hydroxycyclopentane-1-carboxylate;79590-84-4;(1S,3R)-3-Hydroxycyclopentane carboxylic acid methyl ester;SCHEMBL417483;Cyclopentanecarboxylic acid, 3-hydroxy-, methyl ester;DTXSID601215959;Methyl3-hydroxycyclopentanecarboxylate;MFCD20040367;SB11634;SB12598;SB34265;SB45203;SB84025;BS-17013;CS-0150733;FT-0720628;EN300-312932;P17887;methyl (1S)-3-hydroxycyclopentane-1-carboxylate;Pentanecarboxylic acid, 3-hydroxy-, methyl ester

Chemical Property of Methyl 3-hydroxycyclopentanecarboxylate

Chemical Property:

• Boiling Point: 106 °C(Press: 15 Torr)
• PKA: 14.84±0.40(Predicted)
• PSA: 46.53000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 0.32040
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 144.078644241
• Heavy Atom Count: 10
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-cyclopentanecarboxylicacidmethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CCC(C1)O

Technology Process of Methyl 3-hydroxycyclopentanecarboxylate

There total 5 articles about Methyl 3-hydroxycyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 3-oxocyclopentane-1-carboxylate (32811-75-9) → 3-hydroxycyclopentanecarboxylic acid methyl ester (32811-76-0,1292307-06-2)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃; for 0.5h;

Reference yield:

methyl cyclopent-3-ene-1-carboxylate (58101-60-3) → 3-hydroxycyclopentanecarboxylic acid methyl ester (32811-76-0,1292307-06-2)

Guidance literature:

With isoamylborane; dihydrogen peroxide; Yield given. Multistep reaction;

DOI:10.1021/jo01313a014

Reference yield:

→ Methyl-cis-3-hydroxy-cyclopentan-1-carboxylat (32811-76-0,58101-61-4,58101-62-5,79590-84-4,79598-73-5,1292307-06-2)

Guidance literature:

3-Oxocyclopentan-1-carboxylat (s.F. III), NaBH4, (neben Verb. IXb-trans);

upstream raw materials:

methyl 3-oxocyclopentane-1-carboxylate

methyl cyclopent-3-ene-1-carboxylate

3-Oxo-cyclopentanecarboxylic acid

Downstream raw materials:

(+/-)-cis-3-hydroxy-cyclopentanecarboxylic acid

methyl 3-(5-bromopyridin-2-yloxy)cyclopentane carboxylate

(+/-)-cis-3-methoxy-cyclopentanecarboxylic acid p-toluidide

(+/-)-cis-3-hydroxy-cyclopentanecarboxylic acid p-toluidide