(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid
• CAS No.: 959583-52-9
• Molecular Formula: C17H22FNO4
• Molecular Weight: 323.364
• DSSTox Substance ID: DTXSID10376001
• Wikidata: Q82164742
• Mol file: 959583-52-9.mol

Synonyms:959583-52-9;(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid;Boc-(R)-gamma-(4-fluoro-benzyl)-L-proline;(2S,4R)-4-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)-pyrrolidine-2-carboxylic acid;trans-N-Boc-4-(4-fluorobenzyl)-L-proline;SCHEMBL1371619;Boc-Pro{4-Bzl(4-F)}-OH;DTXSID10376001;FGLYPQZHYLRBOI-OCCSQVGLSA-N;MFCD06659391;AKOS015949645;DS-6164;(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylicacid;CS-0179140;A858749;(2S,4R)-1-BOC-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid;(2S,4R)-1-[(tert-butoxy)carbonyl]-4-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid;N-t-Butoxycarbonyl-trans-4-(4-fluorobenzyl)-L-proline;(2S,4R)-1-t-Butoxycarbonyl-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid

Chemical Property of (2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid

Chemical Property:

• Melting Point: 123-125℃
• PSA: 66.84000
• LogP: 3.01630
• Storage Temp.: 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 323.15328635
• Heavy Atom Count: 23
• Complexity: 440

Purity/Quality:

97% ^*data from raw suppliers

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)-pyrrolidine-2-carboxylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CC(CC1C(=O)O)CC2=CC=C(C=C2)F
• Isomeric SMILES: CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)CC2=CC=C(C=C2)F

Technology Process of (2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid

There total 6 articles about (2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S,4R)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid (1049977-93-6) → (2S,4R)-1-(tert-butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid (959583-52-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/jm201533b

Reference yield:

(2S,4R)-1-tert-butyl 2-ethyl 4-(4-fluorobenzyl)pyrrolidine-1,2-dicarboxylate → (2S,4R)-1-(tert-butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid (959583-52-9)

Guidance literature:

(2S,4R)-1-tert-butyl 2-ethyl 4-(4-fluorobenzyl)pyrrolidine-1,2-dicarboxylate; With water; lithium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; at 0 ℃; pH=< 3;

Reference yield:

di-tertbutyl (2S,4R)-4-(4-fluorobenzyl)pyrrolidine-1,2-dicarboxylate → (2S,4R)-1-(tert-butoxycarbonyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid (959583-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; acetonitrile / 24 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/jm201533b

upstream raw materials:

di-tert-butyl dicarbonate

(2S,4R)-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid

C₂₁H₂₈FNO₅

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate

Downstream raw materials:

(2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide

XL₅₄₁

(2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide

(2S,4R)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide

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