(1,1'-Biphenyl)-4-methanamine, N-(2-methylpropyl)-2'-(1-pyrrolidinylsulfonyl)-, hydrochloride (1:1)

Base Information

Chemical Name:(1,1'-Biphenyl)-4-methanamine, N-(2-methylpropyl)-2'-(1-pyrrolidinylsulfonyl)-, hydrochloride (1:1)
CAS No.:1322001-35-3
Molecular Formula:C₂₁H₂₈N₂O₂S*ClH
Molecular Weight:408.992
Hs Code.:
UNII:W2XT1FW9V4
DSSTox Substance ID:DTXSID50157432
Wikipedia:PF-4455242

Synonyms:2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine;2-methyl-N-(2'-(pyrrolidinyl-1-ylsulfonyl)-(1,1'-biphenyl)-4-yl)propan-1-amine;PF 4455242;PF-04455242;PF-4455242;PF4455242

Suppliers and Price of (1,1'-Biphenyl)-4-methanamine, N-(2-methylpropyl)-2'-(1-pyrrolidinylsulfonyl)-, hydrochloride (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of (1,1'-Biphenyl)-4-methanamine, N-(2-methylpropyl)-2'-(1-pyrrolidinylsulfonyl)-, hydrochloride (1:1)

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:408.1638270
Heavy Atom Count:27
Complexity:515

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CNCC1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)N3CCCC3.Cl

Technology Process of (1,1'-Biphenyl)-4-methanamine, N-(2-methylpropyl)-2'-(1-pyrrolidinylsulfonyl)-, hydrochloride (1:1)

There total 4 articles about (1,1'-Biphenyl)-4-methanamine, N-(2-methylpropyl)-2'-(1-pyrrolidinylsulfonyl)-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929000-58-8
1-((2-bromophenyl)sulfonyl)pyrrolidine

: 1322001-35-3
2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / 1,2-dimethoxyethane / 4 h / Reflux; Inert atmosphere

2.1: dichloromethane / 0.5 h / Inert atmosphere

3.1: sodium tris(acetoxy)borohydride / dichloromethane / Inert atmosphere

3.2: Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium tris(acetoxy)borohydride; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; 1.1: Suzuki coupling;
DOI:10.1021/jm2006035

Reference yield:

: 1202647-49-1
2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-carbaldehyde

: 1322001-35-3
2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / dichloromethane / Inert atmosphere

2.2: Inert atmosphere

With sodium tris(acetoxy)borohydride; In dichloromethane;
DOI:10.1021/jm2006035

Reference yield:

: C₂₁H₂₆N₂O₂S

: 1322001-35-3
2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride

Guidance literature:: C₂₁H₂₆N₂O₂S; With sodium tris(acetoxy)borohydride; In dichloromethane; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; Inert atmosphere;
DOI:10.1021/jm2006035